نتایج جستجو برای: CCL5

تعداد نتایج: 2037  

Objective(s): Aberrant expression of CCL5 has been found in several kinds of inflammatory diseases, and the roles of CCL5 in these diseases have also been reported. However, the role of CCL5 in infantile pneumonia is still unclear. Thus, the function and acting mechanism of CCL5 in the in vitro model of infantile pneumonia were researched in this study. Materials and Methods: Human fetal lung f...

Background: inflammatory chemokines such as CCL2 and CCL5 are involved in the progress of osteoarthritis. Crocin with antioxidant and anti-inflammatory properties can reduce the symptoms of osteoarthritis (OA). This study was performed investigate the effect of Krocina™, on the gene expressions and plasma levels of CCL2 and CCL5 in OA patients. Methods: The study included 35 patients that we...

Journal: :Journal of leukocyte biology 2015
Rundk Hwaiz Milladur Rahman Ingvar Syk Enming Zhang Henrik Thorlacius

Accumulating evidence suggest that platelets play an important role in regulating neutrophil recruitment in septic lung injury. Herein, we hypothesized that platelet-derived CCL5 might facilitate sepsis-induced neutrophil accumulation in the lung. Abdominal sepsis was induced by CLP in C57BL/6 mice. CLP increased plasma levels of CCL5. Platelet depletion and treatment with the Rac1 inhibitor NS...

2014
Guan-Ting Liu Hsien-Te Chen Hsi-Kai Tsou Tzu-Wei Tan Yi-Chin Fong Po-Chen Chen Wei-Hung Yang Shih-Wei Wang Jui-Chieh Chen Chih-Hsin Tang

Chondrosarcoma is the second most common primary malignant bone cancer, with potential for local invasion and distant metastasis. Chemokine CCL5 (formerly RANTES) of the CC-chemokine family plays a crucial role in metastasis. Angiogenesis is essential for the cancer metastasis. However, correlation of CCL5 with vascular endothelial growth factor (VEGF) expression and angiogenesis in human chond...

Journal: :Molecular medicine reports 2014
Jingcheng Zhang Jia Luo Fanrong Liu Dongmei Wu Qingling Zhong Liangtao Zeng Ziqing Wu Tong Zhao Liqing Wu Hua Hao

There is much evidence suggesting that CCL5 is one of the chemoattractant cytokines involved in diabetes mellitus (DM) with diffuse large B‑cell lymphoma (DLBCL). However, the pathological impact is unclear. In the current study, in order to improve understanding regarding the role of CCL5 in DM with DLBCL, the expression levels of CCL5 mRNA were examined in normal B cells, human DLBCL cell lin...

Journal: :The Journal of clinical investigation 2010
Marie-Luise Berres Rory R Koenen Anna Rueland Mirko Moreno Zaldivar Daniel Heinrichs Hacer Sahin Petra Schmitz Konrad L Streetz Thomas Berg Nikolaus Gassler Ralf Weiskirchen Amanda Proudfoot Christian Weber Christian Trautwein Hermann E Wasmuth

Activation of hepatic stellate cells in response to chronic inflammation represents a crucial step in the development of liver fibrosis. However, the molecules involved in the interaction between immune cells and stellate cells remain obscure. Herein, we identify the chemokine CCL5 (also known as RANTES), which is induced in murine and human liver after injury, as a central mediator of this int...

Journal: :Journal of immunology 2011
Nicole L Sullivan Christopher S Eickhoff Xiuli Zhang Olivia K Giddings Thomas E Lane Daniel F Hoft

Trypanosoma cruzi is an intracellular parasite and the causative agent of Chagas disease. Previous work has shown that the chemokine receptor CCR5 plays a role in systemic T. cruzi protection. We evaluated the importance of CCR5 and CCL5 for mucosal protection against natural oral and conjunctival T. cruzi challenges. T. cruzi-immune CCR5(-/-) and wild-type C57BL/6 mice were generated by repeat...

Journal: :Biochemical pharmacology 2010
Chih-Hsin Tang Ayaho Yamamoto Yuh-Tzy Lin Yi-Chin Fong Tzu-Wei Tan

CCL5 (previously called RANTES) was originally recognized as a product of activated T cells, and plays a crucial role in the migration and metastasis of human cancer cells. It has been reported that the effect of CCL5 is mediated via CCR receptors. We found that human chondrosarcoma tissues had significant expression of the CCL5 and CCR5, which was higher than that in normal cartilage. We also ...

2012
Huan Liu Huan Ning Hongchao Men Rong Hou Mingui Fu Hailin Zhang Jianguo Liu

Chemokines play a crucial role in inflammation and in the pathophysiology of atherosclerosis by recruiting inflammatory immune cells to the endothelium. Chemokine CCL5 has been shown to be involved in atherosclerosis progression. However, little is known about how CCL5 is regulated in vascular smooth muscle cells. In this study we report that CCL5 mRNA expression was induced and peaked in aorta...

2016
Kristi Huik Radko Avi Merit Pauskar Eveli Kallas Ene-Ly Jõgeda Tõnis Karki Kristi Rüütel Ave Talu Katri Abel-Ollo Anneli Uusküla Andrew Carrillo Sunil K. Ahuja Weijing He Irja Lutsar

OBJECTIVE The role of CC chemokine receptor 5 (CCR5) and its ligand CCL5 on the pathogenesis of HIV infection has been well studied but not for HCV infection. Here, we investigated whether CCL5 haplotypes influence HIV and HCV seropositivity among 373 Caucasian people who inject drugs (PWID) from Estonia. METHODS Study included 373 PWID; 56% were HIV seropositive, 44% HCV seropositive and 47%...

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