PURPOSE Cell adhesion molecules (CADM) comprise a newly identified protein family whose functions include cell polarity maintenance and tumor suppression. CADM-1, CADM-3, and CADM-4 have been shown to act as tumor suppressor genes in multiple cancers including prostate cancer. However, CADM-2 expression has not been determined in prostate cancer. EXPERIMENTAL DESIGN The CADM-2 gene was cloned...

Download pose: Cell adhesion molecules (CADM) comprise a newly identified protein family whose funcinclude cell polarity maintenance and tumor suppression. CADM-1, CADM-3, and CADM-4 have shown to act as tumor suppressor genes in multiple cancers including prostate cancer. However, -2 expression has not been determined in prostate cancer. erimental Design: The CADM-2 gene was cloned and charact...

Recently, a test of congruence among distance matrices (CADM) has been developed. The null hypothesis is the incongruence among all data matrices. It has been shown that CADM has a correct type I error rate and good power when applied to independently-generated distance matrices. In this study, we investigate the suitability of CADM to compare ultrametric distance matrices. We tested the type I...

The clinical features of dermatomyositis (DM) have a close relationship with myositis-specific antibodies. Clinically amyopathic dermatomyositis (CADM) is a subgroup of DM, which manifests as characteristic skin symptoms compatible with DM, such as Gottron's sign and heliotrope rash with no or mild muscle symptoms. Sometimes, a life-threatening rapidly progressing interstitial lung disease can ...

Clinically amyopathic dermatomyositis (CADM) is an uncommon subtype of dermatomyositis that rarely presents simultaneously with psoriasis. There are subsequently few reports discussing the management of concurrent CADM and psoriasis. Furthermore, skin lesions of CADM are often recalcitrant to first line dermatomyositis interventions. We present a case of a 45-year-old woman with both CADM and p...

Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are specific indicators of patients with dermatomyositis, particularly clinically amyopathic dermatomyositis (CADM). CADM is occasionally accompanied by fatal, treatment-resistant, rapidly-progressive interstitial lung disease (RP-ILD). All previous reports showed that histopathological findings in RP-ILD with anti-MDA5 antibody-...

BACKGROUND Interstitial lung disease (ILD) is a common manifestation of polymyositis (PM), dermatomyositis (DM), and clinically amyopathic dermatomyositis (CADM); however, little is known about the factors influencing the prognosis for PM/DM/CADM-associated ILD. (PM/DM/CADM-ILD). The aim of the present study is to assess prognostic factors for PM/DM/CADM-ILD. METHODS The clinical features and...

Dermatomyositis (DM) associated with anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is a rare autoimmune disease. Anti-MDA5, also known as anti-CADM-140 antibodies. DM affects the skeletal muscle, skin, joints, and lungs form of idiopathic inflammatory myopathy (IIM). All dermatomyositis MDA5+ positive patients had rapidly progressive interstitial lung disease (RP-ILD). cl...

Vascular abnormalities are one of the common features in rheumatic diseases, but their pathogenesis is still not known. Angiogenin, a molecule implicated in the angiogenic process, may play some roles in such vascular changes. Serum angiogenin concentrations were measured in 21 scleroderma patients, 10 patients with systemic lupus erythematosus (SLE), 21 patients with dermatomyositis (DM), 5 pa...

The aims of this study were to retrospectively review Japanese consecutive cases of polymyositis (PM), dermatomyositis (DM), and clinically amyopathic dermatomyositis (CADM), focusing on interstital lung disease (ILD) and malignancy, and to document any differences in the incidence, clinical features, and impact on prognosis among patients with PM, DM, and CADM. We retrospectively reviewed 62 c...