objective(s)progesterone is a steroid hormone whose biology has been greatly studied within the confines of reproductive function. in recent years, the neuroprotective effects of progesterone have attracted growing interest. glial cell line-derived neurotrophic factor (gdnf), is a neurotrophic factor which plays a crucial role in the development and maintenance of distinct sets of central and p...

Background: Selective phosphodiesterase (PDE3) inhibitors improve cardiac contractility and may use in congestive heart failure. However, their proarrhythmic potential is the most important side effect. Methods: In this research, we evaluated the potential cardiotonic activity of six new synthesized selective PDE3 inhibitors (6-hydroxy-4-methylquinolin-2(1H)-one derivatives) using the spontan...

Background: Neck roots lesion is one of the reasons for cervical and arm pain. A detailed patient evaluation could improve diagnose, reduce imaging requests, and speedy treatment of cervical pain. We tried to estimate the utility of pronator teres reflex in C6 and C7 roots irritation. Methods: Present study is composed of 118 participants including 56 with C6 and C7 lesion and 62 normal contro...

background: selective phosphodiesterase (pde3) inhibitors improve cardiac contractility and may use in congestive heart failure. however, their proarrhythmic potential is the most important side effect. methods: in this research, we evaluated the potential cardiotonic activity of six new synthesized selective pde3 inhibitors (6-hydroxy-4-methylquinolin-2(1h)-one derivatives) using the spontaneo...

Ceramides are potent bioactive molecules in cells. However, they are very hydrophobic molecules, and difficult to deliver efficiently to cells. We have made fluid bilayers from a short-chain D-erythro-ceramide (C6-Cer) and cholesteryl phosphocholine (CholPC), and have used this as a formulation to deliver ceramide to cells. C6-Cer complexed with CholPC led to much larger biological effects in c...

PURPOSE The aim of this study was to investigate the role of de novo glutamine (Gln) synthesis in the proliferation of C6 glioma cells and its detection with (13)N-ammonia. METHODS Chronic Gln-deprived C6 glioma (0.06C6) cells were established. The proliferation rates of C6 and 0.06C6 cells were measured under the conditions of Gln deprivation along with or without the addition of ammonia or ...

Complement component C6 is a part of the lytic membrane attack complex formed during complement activation. Animal modeling to define the role of C5a vs. C5b-9 in human disease has used rodents deficient in C6, yet the molecular basis for the deficiencies has not been ascertained. Oligonucleotides derived from a 493 bp EST sequence of the rat C6 gene were used to isolate full-length transcripts...