Objectives Biofilm infections of intravascular catheters caused by Staphylococcus aureus may be treated with catheter lock solutions (CLSs). Here we investigated the antibacterial activity, cytotoxicity and CLS potential of 5-hydroxyethyl-3-tetradecanoyltetramic acid (5HE-C14-TMA) compared with the related compounds 3-tetradecanoyltetronic (C14-TOA) and 3-tetradecanoylthiotetronic (C14-TTA), wh...

(1) In order to study the relationship between the energy metabolism via TCA cycle and amino acid metabolism as well as protein synthesis, C14-labelled substrates were used for tracer experiment . (2) Considerable C14O2 formation was noted from carbohydrates such as acetate-1-C14, pyruvate-1-C14, and pyruvate-3-C14, while a smaller amount of C14O2 was produced from amino acids such as glycine1-...

Protein N-myristoylation occurs by a covalent attachment of a C14:0 fatty acid to the N-terminal Gly residue. This reaction is catalyzed by a N-myristoyltransferase that uses myristoyl-coenzyme A as substrate. But proteins in the retina also undergo heterogeneous N-acylation with C14:2, C14:1, and C12:0 fatty acids. The basis and the role of this retina-specific phenomenon are poorly understood...

To gain further information on the mechanisms by which the fluorinated pyrimidines and their nucleosides inhibit various processes of nucleic acid biosynthesis, studies similar to those re ported in the preceding paper (6) were carried out in vitro in glycolyzing suspensions of the Ehrlich ascites cells system used by LePage for studies of purine biosynthesis (20). In this work the following la...

The activin and TGF-beta type II receptors are members of a separate subfamily of transmembrane receptors with intrinsic protein kinase activity, which also includes the recently cloned TGF-beta type I receptor. We have isolated and characterized a cDNA clone (C14) encoding a new member of this subfamily. The domain structure of the C14-encoded protein corresponds with the structure of the othe...

DOI: 10.1002/elps.202000086 The cover picture shows the determination of four alkyl sulfate (AS) surfactants (C14, C12, C10, and C8) by capillary electrophoresis (CE) after preconcentration simultaneous adsorption AS on Al2O3 surface. EOF electroosmotic flow (EOF) at high pH pushes move to contactless conductivity detector (C4D). electropherograms show separation in order C14, C8.

When Ca-755 tumors of various sizes were treated with three doses of C14-labeled 6-thioguanine (10 mg/kg at 24-hour intervals) the specific activities of their deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) at the end of the treatment were independent of the starting size of the tumor. During the subsequent rapid tumor regression the specific activity of DNA and RNA decreased linearly w...