A convenient and practical synthesis of imidazol-1-yl-acetic acid hydrochloride was achieved via N-alkylation of imidazole using tert-butyl chloroacetate followed by a non-aqueous ester cleavage of the resulting imidazol-1-yl-acetic acid tert-butyl ester in the presence of titanium tetrachloride. The synthesized imidazol-1-yl-acetic acid hydrochloride was then utilized to prepare zoledronic acid.

Distribution coefficients of acetic acid between aqueous phase and solvents (water-C6-C10 alcohols, butyl acetate, ether and benzene) were studied. Synergetic effect was obtained for alcohol and ester systems. A slightly positive deviation was obtained for benzene–ester mixtures. The best distribution coefficient was obtained for hexanol-butyl acetate systems. The coefficients of Redlisch-Kiste...

We report the synthesis and characterization of amino acid ester based chiral ionic liquids, derived from L- and D-alanine tert butyl ester chloride. The synthesis was accomplished via an anion metathesis reaction between commercially available L- and D-alanine tert butyl ester chloride using a variety of counterions such as lithium bis (trifluoromethane) sulfonimide, silver nitrate, silver lac...

An interesting observation was found during our continued studies on the hydrolysis of ibuprofen esters by Candida rugosa lipase (CRL). An important role is played by pH in the stereospecific hydrolysis of these esters. The flap region of CRL plays a significant role in the access of the substrate to the active site of the enzyme. At pH 5.6, 48% of the methyl ester and 5% of the butyl ester of ...

In the present research, synthesis of butyl oleate ester from oleic acid and butanol using loofa-immobilized Rhizopus oryzae as a whole cell biocatalyst (LIC) was studied in which hexane was used as the hydrophobic solvent. Decrease of mass transfer limitations as result of the interface formation between the two immiscible substrates, positively affected on the reaction progress (87% as the es...

Homogeneous linear poly(tartrate ester) ligands provide high chemical yields and enantiomeric excesses in the epoxidation of trans-hex-2-en-1-ol using Ti(OPr)4-tert-butyl hydroperoxide. Branched poly(tartrate ester) can be use as heterogeneous ligands in the epoxidation of trans-hex-2-en-1-ol using Ti(OPr)4-tert-butyl hydroperoxide. Removal and recovery of the polymer catalyst is a simple filtr...

We investigated the in vitro metabolism of two (nitrooxy)butyl ester nitric oxide (NO) donor derivatives of flurbiprofen and ferulic acid, [1,1'-biphenyl]-4-acetic acid-2-fluoro-alpha-methyl-4-(nitrooxy)butyl ester (HCT 1026) and 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid 4-(nitrooxy)butyl ester (NCX 2057), respectively, in rat blood plasma and liver subcellular fractions compared with (nit...

DGBA 1 Diethylene Glycol n-Butyl Ether Acetate (CAS# 124-17-4) (Synonyms: Butyl carbitol acetate; Butyl diglycol acetate; 2-(2-Butoxyethoxy)ethanol acetate; 2(2-Butoxyethoxy)ethyl acetate; Acetic acid 2-(2-butoxyethoxy)ethyl ester; Butoxyethoxyethyl acetate; Butyl carbitol acetate; Butyl diethylene glycol acetate; Diethyleneglycol monobutyl ether acetate; Diglycol monobutyl ether acetate; Ektas...

Abstract Catalytic ester-interchange reactions, analogous to mutation and recombination, allow new sequence information be written statistically into poly(ester-imide) chains based on NDI (1,4,5,8-naphthalenetetracarboxylic diimide) units. Thus, both the insertion of cyclic ester cyclopentadecanolide (“exaltolide”) an NDI-based homopolymer quantitative exchange between two different homopoly(es...

This highlight review describes the recent development of an electrophile-triggered 1,2-metallate rearrangement organoboronic ester ate-complex, which proceeds through 1,2-difunctionalization carbon–carbon σ- and π-bonds, using strain energy as a driving force. Coupling reactions small ring carbocyclic boronic esters, such cyclopropyl-, bicyclo[1.1.0]butyl-, cyclopropenyl-boronic ester, are sum...