The purpose of the present work was to prepare buccal adhesive tablets of miconazole nitrate. The simplex centroid experimental design was used to arrive at optimum ratio of carbopol 934P, hydroxypropylmethylcellulose K4M and polyvinylpyrollidone, which will provide desired drug release and mucoadhesion. Swelling index, mucoadhesive strength and in vitro drug release of the prepared tablet was ...

Nifedipine is an antihypertensive BCS class II drug which has poor bioavailability when given orally. The objective of the present study was to increase the bioavailability of nifedipine, by formulation and evaluation of a buccoadhesive liquisolid system using magnesium aluminium silicate (Neusilin) as both carrier and coating material and dissolution media were selected based on the solubility...

Terbutaline sulfate exhibits extensive first pass metabolism and a short elimination half life which makes frequent oral administration of the drug inevitable. A novel buccoadhesive controlled delivery system of the drug can easily overcome the problem. A two-layered core tablet composed of a fast release layer made of mannitol, lactose, PEG and the drug attached to a sustained release layer co...

Purposes: Propranolol HCl is a beta blocker commonly used worldwide; however, it shows a low bioavailability due to its extensive first-pass metabolism. To solve this problem, a novel drug delivery system such as buccoadhesive system might be helpful. The aim of the present investigation is to prepare the buccoadhesive tablet of propranolol HCl using different mucoadhesive polymers. Method: Buc...

Purposes: Propranolol HCl is a beta blocker commonly used worldwide; however, it shows a low bioavailability due to its extensive first-pass metabolism. To solve this problem, a novel drug delivery system such as buccoadhesive system might be helpful. The aim of the present investigation is to prepare the buccoadhesive tablet of propranolol HCl using different mucoadhesive polymers. Method: Buc...

1. Yong CS, Jung JH, Rhee JD, Kook KC, Choi HG. Physicochemical characterization and evaluation of buccal adhesive tablets containing omeprazole. Drug Develop Ind Pharm 2001;27:447-55. 2. Martindale-The complete drug reference. In: Sweetman SC, editor. London: Pharmaceutical Press; 2005. 3. Clarke’s Analysis of Drugs and Poisons. In: Moffat AC, Osselton MD, Widdop B, editors. London: Pharmaceut...

The aim of the study was to prepare and evaluate bucco-adhesive tablets of rabeprazole sodium that avoid gastric degradation and first pass metabolism, thereby increasing the drug bioavailability and onset of action. The drug, rabeprazole sodium, belongs to a class of antisecretory compounds. In the present work, different ratios of Gantrez MS 955 along with HPMC K4M were studied to give bioadh...

terbutaline sulfate exhibits extensive first pass metabolism and a short elimination half life which makes frequent oral administration of the drug inevitable. a novel buccoadhesive controlled delivery system of the drug can easily overcome the problem. a two-layered core tablet composed of a fast release layer made of mannitol, lactose, peg and the drug attached to a sustained release layer co...

*Corresponding author: Amit Gupta School of Pharmacy and Technology Management SVKM’s NMIMS Deemed University Mumbai400056 Maharastra, India Telephone number: +91-2264521148/49/50 Fax: +91 22 26185422 E-mail: [email protected] [email protected] [email protected] Abstract: Extended release Buccoadhesive buccal tablet for delivery of Nisoldipine were developed using Progressive hydration ...