Syntheses of two 4-phenylpiperidines from bromobenzene have been developed involving anchoring to a fluorous-tag, Ir-catalysed borylation, Pd- and Co-catalysed elaboration then traceless cleavage. Although performed using 'cold' (i.e. unlabelled) bromobenzene as the starting material, these routes have been designed to minimise material loss via volatile intermediates and expedite purification ...

Hepatic Microsomal Epoxidation of Bromobenzene to Phenols and Its Toxicological Implication. LAU, S. S. AND ZANNONI, V. G. (1979). Toxicol. Appl. Pharmacol. 50, 309318. In vitro microsomal hepatic epoxidation of bromobenzene in rats and mice is presented in this study. Formation of o-bromophenol via bromobenzene-2,3-epoxide and p-bromophenol via bromobenzene-3,4-epoxide was assayed enzymaticall...

OBJECTIVE The purpose of the present study was to evaluate the nephroprotective and antioxidant properties of Triphala against bromobenzene-induced nephrotoxicity in female Wistar albino rats. METHODS Animals were divided into five groups of six rats and treated as follows: Group I was a normal control and received no treatment, Group II received only bromobenzene (10 mmol/kg), Groups III and...

The present study investigated the possible protective role of Withania somnifera (Linn.) Dunal (Solanaceae) root powder against bromobenzene-induced oxidative damage in rat liver mitochondria. Administration of bromobenzene (10 mmol/kg body weight) to rats resulted in increased levels of liver marker enzymes, lipid peroxidation, TNF-α, IL-1β and VEGF. There was also marked depletion in the lev...

Liver damage can be induced by drugs or chemicals resulting from overdose or workplace exposure. Bromobenzene is an efficient model to perform studies on hepatotoxicity. After biotransformation into liver,it causes production of reactive oxygen species (ROS). Organs that have been found to be affected due to bromobenzene induced toxicity are liver, kidney and lungs. In the following review, mec...

Liver is a major organ of the body which can be exposed to various chemicals, drugs, and many other xenobiotics such as bromobenzene. Bromobenzene must be converted to its active metabolites to produce liver and kidney toxicity. Livergol is an herbal product which contains silymarin. The objective of this study was to find out the protective effect of livergol against liver toxicity induced by ...

bromophenol is formed from bromobenzene-3,4-oxide nonenzymically, the decrease in p-bromophenol formation may be used as an indirect measure of the decrease in the extracellular concentration of bromobenzene-3,4-oxide in the presence of the transferase. From these data, we found that only negligible amounts of the epoxide re-entered the cells; that is, kZ1 was negligible and that about 59% of t...

Enantiomerically pure (S)-tributylstannyl[D1]methanol and (R)- and (S)-tributylstannyl[D1]methyl benzoates were Stille-coupled with bromobenzene and benzoyl chloride in 1,4-dioxane and toluene using [(Ph3P)4Pd] or [(Ph3P)2PdCl2] either alone or in combination with CuCN as cocatalyst at temperatures up to 80 °C. The products were found to be enantiomerically pure. (R)- and (S)-N-(tributylstannyl...

liver is a major organ of the body which can be exposed to various chemicals, drugs, and many other xenobiotics such as bromobenzene. bromobenzene must be converted to its active metabolites to produce liver and kidney toxicity. livergol is an herbal product which contains silymarin. the objective of this study was to find out the protective effect of livergol against liver toxicity induced by ...