Objective(s): The current study reports investigation of codelivery by PLGA nanoparticles (NPs) loaded with crocetin (Cro), a natural carotenoid dicarboxylic acid that is found in the crocus flower, and Doxorubicin (DOX). Materials and Methods: Double emulsion/solvent evaporation method was used for preparation of PLGA nanoparticles containing Dox and Cro. Characterizations of prepared NPs were...

background and objective: it is well known that menstrual period and ovarian function are affected by chemotherapy. although breast cancer is the most common cause of chemotherapy in women and ovarian hormones have very important direct and indirect effects on overall survival, disease-free survival, and life quality of patients, but few studies have addressed the frequency and related factors ...

background: full blood count has been shown to predict disease severity and mortality risk in cancer patients. this study aimed to highlight the degree of derangements of full blood count parameters and provide mean values in pre-chemotherapy breast cancer patients compared with apparently normal control subjects.methods: this was an unmatched case-control study among breast cancer patients att...

background: thioredoxin reductase 1 (txnrd1) and thioredoxin interacting protein (txnip) also known as thioredoxin binding protein 2 or vitamin d3-upregulated protein 1 are key players in oxidative stress control. thioredoxin (trx) is one of the major components of the thiol reducing system and plays multiple roles in cellular processes. computational analyses of txnrd1, txnip and trx expressio...

evaluation of the effects of educational package on controlling the complications of chemotherapeutic agents on symptom scales of quality of life in patients with breast cancer undergoing chemotherapy    baghaei r [1] *, sharifi m [2] , mohammadpour y [3] , sheykhi n [4]     received: 9 jul , 2013 accepted: 14 sep , 2013    abstract  background & aims : today breast cancer is the most common ma...

background: anxiety is the most prevalent psychological side effect of breast cancer and chemotherapy. this study aimed to determine the effect of slow stroke back massage (ssbm) on the anxiety of old female patients with breast cancer undergoing chemotherapy. methods: in this quasi-experimental study, 80 elderly women with breast cancer undergoing chemotherapy were enrolled by continuous sampl...

results the results showed that the mean scores of nausea in the control group was increased from 2.97 on the first day to 3.26 and in the intervention group was decreased from 3.44 to 1.52 at the end of trial. however there was not any significant difference in the first, second, third and fourth days between two groups. conclusions massage can reduce nausea. however further studies with large...

background : in this study we evaluated the knowledge and practice of patients with breast cancer about complication of chemotherapy referred to chemotherapy ward of nemazee hospital in shiraz, shiraz province, iran, in 2004. methods: forty patients suffering breast cancer and under chemotherapy, were selected with a simple random sampling method. all were interviewed and a questionnaire was co...

abstract background: nausea and vomiting are the worst and the most prevalent complications experienced by 70–80% of patients. complementary treatments including therapeutic touch are cost‑effective and low‑risk, independent nursing interventions. present research aims at investigating the effect of therapeutic touch on the intensity of acute chemotherapy‑induced vomiting in these patients. mat...

paclitaxel is a highly effective anticancer agent. it is active against a broad range of cancers that are generally considered refractory to conventional chemotherapy. paclitaxel induces a peripheral neuropathy (pn) that is characterized by sensory symptoms such as numbness and paresthesia in a glove and stocking distribution. pn may be severe and dose limiting at initial doses above 275 mg/m2....