(Cell 146, 633–644; August 19, 2011) In theDiscussionof theabovearticle,weneglected tociteChaffer et al. (2011),who recently identifiedplasticity in cancercell populations inwhich non-stemcancer cells cangive rise to cancer stem-like cells. Their findings, togetherwithour analysesof breast cancer cell lines and their ability to regenerate equilibrium populations of stem and non-stem cells, esta...

We have developeda simple and reproducible fingerprinting method for screeningthegenomefor regionsof DNA thathavealteredpatternsof DNA methylationassociatedwith oncogenictransformation.Restriction enzymes with different sensitivities to cytosine methylation in their rec ognition sites were used to digest genomic DNAs from primary tumors, cell lines, and normal tissuesprior to arbitrarily primed...

BACKGROUND. Tranilast is a therapeutic agent used in treatment of allergic diseases, although it has been reported to show anti-tumor effects on some cancer cells. To elucidate the effects of tranilast on prostate cancer, we investigated the mechanisms of its anti-tumor effect on prostate cancer. METHODS. The anti-tumor effects and related mechanisms of tranilast were investigated both in vitro...

The hypothesis that anaesthetic and analgesic technique during cancer surgery affects recurrence or metastasis was first proposed in 2006 and has since become one of the most important research questions in the speciality, as confirmed in a recent research priority setting exercise. Building on the success of the inaugural BJA Workshop on Anaesthetic Neurotoxicity and Neuroplasticity held in Sa...

Cyclooxygenase-2 (COX-2) is a promising target for the imaging of cancer in a range of diagnostic and therapeutic settings. We report a near-infrared COX-2-targeted probe, fluorocoxib C (FC), for visualization of solid tumors by optical imaging. FC exhibits selective and potent COX-2 inhibition in both purified protein and human cancercell lines. In vivo optical imaging shows selective accumula...

MicroRNAs have been broadly implicated in cancer, but their exact function and mechanism in carcinogenesis remain poorly understood. Aberrant miR-486-5p expression is frequently found in human cancers. Here we showed a significant overexpression of miR-486-5p in prostate cancer compared with that in normal tissue and cells, and we proposed that altered expression of miR-486-5p in the prostate c...