Water flooding is a well-known secondary mechanism for improving oil recovery. Conventional approach to evaluate the performance of a water flooding process (e.g. breakthrough and post breakthrough behavior) is to establish a reliable geological reservoir model, upscale it, and then perform flow simulations. To evaluate the uncertainty in the breakthrough time or post breakthrough behavior, thi...

Pain is one of the most common and often most feared symptoms in patients with cancer. Ongoing or progressive pain is physically debilitating and has a marked impact on quality of life. During their illness, at least 70% of patients will experience pain sufficiently severe to require chronic opioid treatment. Moreover, Breakthrough Pain (BTP) consists in transitory exacerbations of pain that oc...

"Breakthrough pain" is a common clinical term that has not been conclusively defined or described. Breakthrough pain is a transitory flare of pain experienced when baseline pain has been reduced to a mild or moderate level. Breakthrough pain may be characterized by its relationship to a fixed around-the-clock (ATC) opioid dose, rapid onset and short duration, precipitating events, predictabilit...