Box and Behnken (1960) constructed 10 three-level, second-order designs, while their 1958 technical report contained seven additional designs. This series of designs is based on combining 2 or 2 designs in different subsets of the t factors, with k < t. The subsets of size k were determined using balanced (or partially balanced) incomplete block designs. This present article offers additional B...

n-methylol dimethyl phosphonopropionamide (mdpa) is one of the most utilized fire resistant (fr) finishes for cotton fabrics, utilized as part of a formulation with trimethylol melamine (tmm) to acquire better crosslinking and enhanced fr properties. the system parameters of the finishing treatment were upgraded for better fr properties and low mechanical loss to the fabric by the response surf...

this study a novel high performance liquid chromatography for the assay of nystatin in oral and vaginal tablets were optimized and validated using box–behnken experimental design. the method was performed in the isocratic mode on a rp-18 column (30 °c) using a mobile phase consisting of 0.05 m ammonium acetate buffer/ methanol mixture (30:70) and a flow-rate of 1.0 ml/min. the method was valida...

fruit waste extract was selected as the sole substrate for carotenoid production and the effect of parameters like ph, temperature and agitation have been studied. a two-step simple sequential strategy was employed for the optimization of carotenoid production by rhodotorula rubra. in the first step, one factor at a time was employed to evaluate the impact of ph on carotenoid production. the ou...

this paper discusses the use of box behnken design (bbd) approach to plan the experiments for turning the yield of cvd, thickness and layer number of graphene sheets with an overall objective of optimizing the process to provide higher graphene production volume, fewer layers and thinness structure of graphene. bbd is having the maximum efficiency for an experiment involving four factors such a...

Using Dachengqi Tang (DCQT) as a model, high performance liquid chromatography (HPLC) fingerprints were applied to optimize machine extracting process with the Box-Behnken experimental design. HPLC fingerprints were carried out to investigate the chemical ingredients of DCQT; synthetic weighing method based on analytic hierarchy process (AHP) and criteria importance through intercriteria correl...

Essential oil components were extracted from Lavandula angustifolia (Lavender) flowers using pressurized fluid extraction (PFE). A Box-Behnken design was used to optimize the effective extraction variables. The chemical composition of extracted samples was analyzed by gas chromatograph-flame ionization detector column. For achieving maximum % extraction yield the temperature, pressure, and dyna...

The present study illustrates the optimization and characterization of β-glucosidase from a bacterial isolate, strain SG9. Sixty-eight different variables were first screened by one factor at a time method. The screened variable optimization was then performed by Plackett-Burman design followed by Box-Behnken response surface methodology. Thirty-one variables were screened, of which five variab...

Background & Aims: High concentrations of selenite have carcinogenetic, cytotoxic and genotoxic effects. Therefore, removal of this toxic pullutant from the environment has a particular importance in maintaining public health. In this study, with the aim of optimization of selenite removal process, the design Box-Behnken method was used to estimate th...