Box and Behnken (1960) constructed 10 three-level, second-order designs, while their 1958 technical report contained seven additional designs. This series of designs is based on combining 2 or 2 designs in different subsets of the t factors, with k < t. The subsets of size k were determined using balanced (or partially balanced) incomplete block designs. This present article offers additional B...

n-methylol dimethyl phosphonopropionamide (mdpa) is one of the most utilized fire resistant (fr) finishes for cotton fabrics, utilized as part of a formulation with trimethylol melamine (tmm) to acquire better crosslinking and enhanced fr properties. the system parameters of the finishing treatment were upgraded for better fr properties and low mechanical loss to the fabric by the response surf...

this study a novel high performance liquid chromatography for the assay of nystatin in oral and vaginal tablets were optimized and validated using box–behnken experimental design. the method was performed in the isocratic mode on a rp-18 column (30 °c) using a mobile phase consisting of 0.05 m ammonium acetate buffer/ methanol mixture (30:70) and a flow-rate of 1.0 ml/min. the method was valida...

fruit waste extract was selected as the sole substrate for carotenoid production and the effect of parameters like ph, temperature and agitation have been studied. a two-step simple sequential strategy was employed for the optimization of carotenoid production by rhodotorula rubra. in the first step, one factor at a time was employed to evaluate the impact of ph on carotenoid production. the ou...

this paper discusses the use of box behnken design (bbd) approach to plan the experiments for turning the yield of cvd, thickness and layer number of graphene sheets with an overall objective of optimizing the process to provide higher graphene production volume, fewer layers and thinness structure of graphene. bbd is having the maximum efficiency for an experiment involving four factors such a...

Response surface methodology was engaged for the optimization of diverse nutritional and physical parameters for laccase production by Streptomyces chartreusis strain NBRC 12753 in the submerged fermentation process. Screening of production parameters was executed using Plackett–Burman design and the variables with statistically momentous effects on laccase production were recognized. Variables...

Box-Behnken designs (Box and Behnken, 1958, 1960) form a very popular class of 3-level second-order designs when the number of factors is small, typically, seven or less. For larger number of factors these designs are not so popular because then, these designs require a large number of runs. This paper provides a catalog of 3-level second-order designs for 5-11 factors with run sizes ≤ 100. All...

a soil bacterium capable of degrading chitin on chitin agar plates was isolated and identified as bacillus pumilus isolate u5 on the basis of 16s rdna sequence analysis. in order to optimize culture conditions for chitinase production by this bacterium, a two step approach was employed. first, the effects of several medium components were studied using the plackett-burman design. among various ...

the current investigation presents the role of gooseberry (phyllanthus acidus) seeds as an effective biosorbent for remediating chromium (vi)), a toxic heavy metal pollutant commonly found in effluents from tanneries and relevant industries. biosorption was affected by ph, temperature and initial metal concentration. furthermore, there is a need to understand the holistic effect of all variable...