Objective(s): In this study, potential protective effects of Bortezomib (Bort), as a proteasome inhibitor, were investigated on the uterus of ovariectomized rats by histological, morphometric and immunohistochemical methods.Materials and Methods: In this study, 18 Sprague dawley strain female rats (12 weeks old, 250-300 g body weight) were used. Animals in the control group (Cont, n=6) were not...

amiodarone is used in treatment of cardiac arrhythmias. therapeutic use of amiodarone is limited by its side effects, including pulmonary toxicity. human placenta extract (hpe) contains a variety of bio-active substances. thus, the present study aimed to quantitatively evaluate the protective effects of hpe on the structural lung changes induced by amiodarone using stereological methods. spragu...

objective: to determine the effects of topical administration of 20% oltipraz solution on histomorphometrical and stereological aspects of skin tissue in full thickness skin wounds in laboratory rats. methods: thirty-six male wistar portion rats (220±20 g) were randomly divided into three groups (n=12). on the first day of experimentation, a 1-cm 2 circular wound was made on the posterior surfa...

the aim of the present study was stereological evaluation of testes of azoospermic animal model using busulfan in rat. three groups of male adult rats were used in this study. the first group was injected by single dose of busulfan (10 mg kg-1) and their testes were removed on day 35 post injection. the second group received double doses of busulfan with 21 days interval and their testes were r...

introduction: several studies indicate that estrogen use increase performance on some tests of cognition especially in postmenopausal women. these steroids have many side effects, thus, other estrogenic agents with fewer side effects are needed to develop alternative treatment strategies. the main objection of this study was to evaluate the effects of different doses of dietary soy meals (with ...

background: para-nonylphenol (p-np) is one of the environmental pollutants which cause reproductive system disorders. objective: the effects of vitamin e on ovary structure during its development in rats treated with p-np. materials and methods: 32 wistar female rats after mating were divided into 4 groups; control vitamin e (100mg/kg/day) p-np (250mg/kg/day) and p-np + vitamin e. the rats were...

background: bisphenol a (bpa), an environmental pollutant, can generate free radicals which damages the reproductive system. vitamin c is an antioxidant which may prevent the adverse effects of free radicals.objective: the aim was to investigate the effect of vitamin c on the ovary tissue in rats treated with bpa.materials and methods: in this experimental study, 24 female wistar rats (200±20 g...

background: vitamin e is an effective antioxidant, protecting cells against oxidative stress. objective: in this investigation the protective effect of vitamin e on the testis during development and spermatogenesis in rats exposed to sodium arsenite was evaluated. materials and methods: pregnant wistar rats were divided into 4 groups (n=8) control, sodium arsenite (8 mg/kg/day), sodium arsenite...

objective: estrogen deficit following menopause results in cognitive behaviors impairment. severity of these impairments in menopause women suffer with cerebral hypo perfusion/ischemia (hi) cause the brain damage and neuronal death. this study aimed to evaluate the effects of pomegranate seed extract (pgse) on avoidance memories after permanent bilateral common carotid arteries occlusion (2ccao...

osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (sns) and bone metabolism. leptin has been shown to regulate bone formation and bone resorption via the sns. however, the effect of sns on leptin signaling has not been clearly understood. in the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...