نتایج جستجو برای: Boron neutron capture therapy (BNCT)
تعداد نتایج: 829713 فیلتر نتایج به سال:
Background: Boron neutron capture therapy (BNCT) is a binary radiotherapy combining biochemical targeting with neutron irradiation. However, monitoring the boron distribution is a fundamental problem in BNCT. Prompt gamma rays emitted by boron capture reaction can be used to address the issue. Materials and Methods: The general-purpose Monte Carlo toolkits Geant4 and MCNP were used for the simu...
Introduction: The Monte Carlo simulation is used to enhance reliability in the experiments related to nuclear instruments. in addition, that is used to calculate the different components of the neutron and gamma ray fluxes in boron neutron capture therapy(BNCT) and neutron capture (NCT)applications. BNCT is one of the methods in radiotherapy, that is used the neutron beam for ki...
Introduction: Boron neutron capture therapy (BNCT) is recommended to treat the glioblastoma tumor. It is well known that neuron beams are more effective treatment than photon beams to treat hypoxia tumors due to interaction of neutron with nucleus and production of heavy particles such as 7Li and alpha particle. In this study to evaluate the suitability of BNCT for treating of ...
Boron neutron capture therapy (BNCT) is based on the nuclear reaction, such that B-10 irradiated with low-energy thermal neutrons produces alpha particles with high linear energy transfer and lithium-7. Clinically, BNCT is used primarily for treatment of high-grade glioma or brain metastases from melanoma and, more recently, head, neck and liver cancers. Since reactors have long been used to pr...
BACKGROUND Boron neutron capture therapy (BNCT) is a unique particle radiation therapy based on the nuclear capture reactions in boron-10. We developed a novel boron-10 containing sodium borocaptate (BSH) derivative, 1-amino-3-fluorocyclobutane-1-carboxylic acid (ACBC)-BSH. ACBC is a tumor selective synthetic amino acid. The purpose of this study was to assess the biodistribution of ACBC-BSH an...
Background and purpose: Boron Neutron Capture Therapy (BNCT) is a promising radiotherapy based on the accumulation of Boron into the tumor and subsequent irradiation with low energy neutrons. It leads to the decay of 10B to 7Li and α particle, causing the death of the neoplastic cells. Here we report some chitosan modified nanoparticles bearing boron phenyl alanine (BPA) as an inexp...
One of the radiotherapy has boron neutron capture therapy (BNCT). They may make it easier to kill tumor cells with BNCT. In BNCT, it is important for boron agents, which have high selectively and high accumulation, to be introduced into tumor cells. To date, the main boron compounds used by the clinical study are sodium mercaptododecaborate (BSH) and pboronophenylalanine (BPA). But, there are n...
An accelerator-based BNCT (Boron Neutron Capture Therapy) facility is now under construction and the entire system including the patient treatment system will be installed in the Ibaraki Medical Center for Advanced Neutron Therapy (tentative name). Investigation of an 8-MeV proton linac and of a beryllium-based neutron production target for the BNCT is progressing. We are aiming at the design a...
An epithermal neutron beam has been designed for Boron neutron Capture Therapy (BNCT) at the thermal column of Tehran Research Reactor (TRR) recently. In this paper the whole body effective dose, as well as the equivalent doses of several organs have been calculated in this facility using MCNPX Monte Carlo code. The effective dose has been calculated by using the absorbed doses determined for e...
This review compares the safety and efficacy of boron neutron capture therapy (BNCT) in the treatment of previously irradiated, inoperable locoregional recurrent HNC patients and compares BNCT against the standard treatment of platinum-based chemotherapy. Our analysis of published clinical trials highlights efficacy of BNCT associated with mild side effects. However, the use of BNCT should be e...
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