currently autografts are gold standards for craniomaxillofacial bone regeneration. but autografts have some limitations. bone tissue engineering has been introduced to overcome these limitations. it consist three components: stem cells, growth factor, and scaffold. scaffold provides an environment for bone growth and simplifies cell adhesion, differentiation and proliferation. in this review, a...

Introduction: The need for biocompatible and bioactive scaffolds to accelerate the regeneration and repair of fractured bones has been considered for bone tissue engineering applications during recent decades. The new methods were developed to produce scaffolds to improve the tissue quality, size of cavities, control the porosity and increase the scaffold compressive strength u...

introduction : deproteinized bovine bone mineral (bio-oss) is a xenogenic bone substitute, widely used in maxillofacial bone regeneration. the aim of this in vitro study was to investigate its influence on the growth behavior of human osteosarcoma cell line, saos-2 culture, and compare it with the physiologic dose of dexamethasone, an inductive factor for osteoblasts. materials and methods: hum...

Background: Spinal cord has a limited capacity to repair therefore, medical interventions are necessary for treatment of injuries. Transplantation of Schwann cells has shown a great promising result for spinal cord injury (SCI). However, harvesting Schwann cell has been limited due to donor morbidity and limited expansion capacity. Furthermore, accessible sources such as bone marrow stem cells ...

Background: In the present study, a tissue engineered silk fibroin (SF) scaffold containing simvastatin-loaded silk fibroin nanoparticles (SFNPs) were used to stimulate the regeneration of the defected bone. Methods: At first, the porous SF scaffold was prepared using freeze-drying. Then simvastatin-loaded SFNPs were made by dissolvation method and embedded in the SF scaffold. Afterwards, the ...

The prototyping of tissue-engineered bone scaffold (calcined goat spongy bone-biphasic ceramic composite/PVA gel) by 3D printing was performed, and the biocompatibility of the fabricated bone scaffold was studied. Pre-designed STL file was imported into the GXYZ303010-XYLE 3D printing system, and the tissue-engineered bone scaffold was fabricated by 3D printing using gel extrusion. Rabbit bone ...

Objective- To determine the effect of selected bone graft on the compression properties of radialbone in rabbit.Design- Experimental in vivo study.Animals- A total of 45 adult male New Zealand white rabbits.Procedures- The rabbits were anesthetized and a one-cm-full thickness piece of radial bone wasremoved using oscillating saw in the all rabbit. The rabbits were divided into 5 groups on theba...

Bioceramic scaffolds such as silicate bioceramics have been widely used for bone tissue engineering. However, their high degradation rate, low mechanical strength and surface instability are main challenges compromising their bioactivity and cytocompatibility which further negatively affect the cell growth and attachment. In this study, we have investigated the effects of silk fibroin coating o...