نتایج جستجو برای: Bone Marrow Lesions (BML)

تعداد نتایج: 464983  

Knee osteoarthritis (OA) affects the joint beyond just the articular cartilage. Specifically, magnetic resonance imagingidentifiedbone marrow lesions (BML) in the subchondral bone have both clinical and pathophysiological significance.Compared to joint space narrowing on traditional radiographs, the presence of BMLs has been better correlated withseverity of clinical symptoms ...

2009
J. Olive T. S. Mair B. Charles

Bone marrow lesions (BMLs) (also known as ‘bone bruises’, ‘bone oedema’, ‘bone contusions’ and ‘occult fractures’) within the middle phalanx were diagnosed by standing low field magnetic resonance imaging (MRI) in 7 horses. The lesions were characterised by low signal intensity on T1and T2*-weighted gradient echo sequences, mildly increased signal intensity on T2 fast spin echo sequences, and h...

Journal: :Arthritis research & therapy 2016
Dzenita Muratovic Flavia Cicuttini Anita Wluka David Findlay Yuanyuan Wang Sophia Otto David Taylor Julia Humphries Yearin Lee Agatha Labrinidis Ruth Williams Julia Kuliwaba

BACKGROUND Bone marrow lesions (BMLs) are useful diagnostic and prognostic markers in knee osteoarthritis (OA), but what they represent at the tissue level remains unclear. The aim of this study was to provide comprehensive tissue characterization of BMLs detected using two specific MRI sequences. METHODS Tibial plateaus were obtained from 60 patients (29 females, 31 males), undergoing knee a...

2014
Jill Halstead Anne-Maree Keenan Dennis McGonagle Philip Conaghan Anthony Redmond

Background Mechanical foot pain is a syndrome in which local pain is associated with musculoskeletal tissues, occurring as a result of mechanical stress. Recent research has indicated that bone marrow lesions (BML) in the knee are associated with mechanical knee pain and increased forces, and that changing the forces within the knee can alter the pattern of BML. As foot orthoses are thought to ...

2016
T. Mark Campbell Sarah M. Churchman Alejandro Gomez Dennis McGonagle Philip G. Conaghan Frederique Ponchel Elena Jones

OBJECTIVE In patients with osteoarthritis (OA), bone marrow lesions (BMLs) are intimately linked to disease progression. We hypothesized that aberrant multipotential stromal cell (also known as mesenchymal stem cell [MSC]) responses within bone tissue contributes to BML pathophysiology. The aim of this study was to investigate BML and non-BML native subchondral bone MSCs for numeric, topographi...

2016
Maurilio Marcacci Luca Andriolo Elizaveta Kon Nogah Shabshin Giuseppe Filardo

Bone marrow lesions (BML) of the knee are a frequent MRI finding, present in many different pathologies including trauma, post-cartilage surgery, osteoarthritis, transient BML syndromes, spontaneous insufficiency fractures, and true osteonecrosis.Osteonecrosis (ON) is in turn divided into spontaneous osteonecrosis (SONK), which is considered to be correlated to subchondral insufficiency fractur...

Journal: :Journal of cartilage & joint preservation 2023

The subchondral bone is a critical part of the osteochondral unit, providing nutrients to overlying articular cartilage, thereby maintaining viability chondral tissue. also provides firm mechanical support assist with stability cartilage and distribution stress. Subchondral pathology, diagnosed as marrow lesion (BML) on magnetic resonance imaging, may be seen in variety pathologic conditions, i...

2015
Camille Roubille Johanne Martel-Pelletier Jean-Pierre Raynauld François Abram Marc Dorais Philippe Delorme Jean-Pierre Pelletier

INTRODUCTION To evaluate the impact of meniscal extrusion (Ext) on knee osteoarthritis (OA) structural progression and on response to strontium ranelate (SrRan) treatment at 36 months in patients with (+) or without (-) Ext, in association (+) or not (-) with bone marrow lesions (BML) in the medial compartment using X-rays (JSW) and qMRI. METHODS Patients from the qMRI substudy of the SEKOIA ...

2014
Flemming K Nielsen Niels Egund David Peters Anne Grethe Jurik

BACKGROUND Longitudinal assessment of bone marrow lesions (BMLs) in knee osteoarthritis (KOA) by MRI is usually performed using semi-quantitative grading methods. Quantitative segmentation methods may be more sensitive to detect change over time. The purpose of this study was to evaluate and compare the validity and sensitivity to detect changes of two quantitative MR segmentation methods for m...

2015
Ming Zhang Jeffrey B. Driban Lori Lyn Price Grace H. Lo Timothy E. McAlindon

Subchondral bone marrow lesions (BMLs) are related to structural and symptomatic osteoarthritis progression. However, it is unclear how sequence selection influences a quantitative BML measurement and its construct validity. We compared quantitative assessment of BMLs on intermediate-weighted fat suppressed (IW FS) turbo spin echo and 3-dimensional dual echo steady state (3D DESS) sequences. We...

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