mefloquine (mfq), as a racemic mixture is used for the prophylaxis and treatment of malaria. stereoselective pharmacodynamic and pharmacokinetic differences have been observed for mfq. in the present study, the human blood was spiked with racemic mfq. the concentration of mfq enantiomers in various blood fractions including packed erythrocyte layer, platelet rich plasma and platelet poor plasma...

       Mefloquine (MFQ), as a racemic mixture is used for the prophylaxis and treatment of malaria. Stereoselective pharmacodynamic and pharmacokinetic differences have been observed for MFQ. In the present study, the human blood was spiked with racemic MFQ. The concentration of MFQ enantiomers in various blood fractions including packed erythrocyte layer, platelet rich plasma and platelet poor...

background: salvia mirzayanii, a native plant to iran, is shown to have immunomodulatory effects on lymphocyte proliferation. objective: to identify the bioactive immunomodulatory compound(s) present in s. mirzayanii. methods: the crude extract was fractionated to five fractions in two steps using different solvents. the fractions were subjected to bioassay-guided fractionation. all the fractio...

Background: Salvia mirzayanii, a native plant to Iran, is shown to have immunomodulatory effects on lymphocyte proliferation. Objective: To identify the bioactive immunomodulatory compound(s) present in S. mirzayanii. Methods: The crude extract was fractionated to five fractions in two steps using different solvents. The fractions were subjected to bioassay-guided fractionation. All the fractio...

Total neutral (nonacidic) glycolipid fractions have been isolated from a gastric adenocarcinoma and the surrounding normal gastric tissue removed at laparotomy of a Blood Group B human individual. Each glycolipid mixture was fractionated by silicic acid column chromatography into ten different partly purified glycolipid fractions. These fractions were analyzed by thin-layer chromatography and t...

this study was aimed at the evaluation of the influence of storage under various conditions on the relative concentrations of major protein fractions and their proportion in bovine serum. blood samples were taken from six dairy cattle of a low-land black spotted breed and its crossbreeds. the separated blood serum was fractioned into aliquots. one aliquot was analysed immediately after the sepa...

the present study was carried out to determine the hypoglycemic activity of the methanolic extract and solvent fractions (n-hexane and ethyl acetate) of ruellia tuberosa in normal and alloxan-induced diabetic rabbits. optimum dose of r. tuberosa for hypoglycemic activity was determined by oral administration of the methanolic extract (me) to normal and diabetic rabbits. diabetes was induced by ...