gator for over 30 years in the field of the nosology of Blaschko-linear diseases. He recently introduced the concept of ‘superimposed segmental manifestation’ to describe severe segmental involvement in polygenic diseases [5] , since the designation ‘type 2 segmental manifestation’ should be restricted to diseases with monogenic mendelian inheritance. Indeed, it is (yet) not possible in polygen...

Focal dermal hypoplasia (FDH) is a rare genetic skin disorder. The inheritance of FDH or Goltz-Gorlin syndrome is X-linked dominant and the disease is associated with a PORCN gene mutation. This gene plays a key role in the Wnt pathway, which has an impact on embryonic development. Every tissue derived from meso- and ectoderm can be affected. Patients suffer from cutaneous, ocular, osseous, ora...

Linear atrophoderma of Moulin (LAM) is a dermatosis characterized by hyperpigmented and depressed band-like lesions localized along the Blaschko lines. This dermatosis was described for the first time by Moulin et al. in five patients with similar characteristics in 1992 and referred to atrophoderma of Moulin, with referrance to the first publication [1,2]. Major characteristics of LAM are bein...

Background: Basaloid follicular hamartomas (BFHs) may occur as single isolated tumors, as localized tumors or as multiple tumors in a disseminated or in a patterned distribution. Non-hereditary multiple and mostly unilateral basaloid follicular hamartomas arranged according to Blaschko`s lines with associated extracutaneous malformations have been designated as a genetic mosaicism disease and o...

Blaschko-linear psoriasis (PBL) is a rare form of that presents as longitudinal lines on the skin, along Blaschko lines. This often observed in children and can be difficult to distinguish from other acquired linear dermatoses such inflammatory verrucous epidermal nevus (ILVEN) lichen striatus. The prevalence PBL unknown, but it generally more common boys than girls. clinical histological simil...