Background: Fluoxetine (FLX) is a selective serotonin reuptake inhibitors antidepressant. FLX affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms. Black Grape seed extract (BGSE) antioxidants neutralize free radicals and oxidative stress. Therefore this study was designed to investigate Protective effect of RGSE hydroa...