Most of the biological phenomena are influenced by intermolecular recognition and interaction. Thus, understanding the thermodynamics of biomacromolecule ligand interaction is a very interesting area in biochemistry and biotechnology. One of the most powerful techniques to obtain precise information about the energetics of (bio) molecules binding to other biological macromolecules is isoth...

most of the biological phenomena are influenced by intermolecular recognition and interaction. thus, understanding the thermodynamics of biomacromolecule ligand interaction is a very interesting area in biochemistry and biotechnology. one of the most powerful techniques to obtain precise information about the energetics of (bio) molecules binding to other biological macromolecules is isothermal...

Confining deoxyribonucleic acid (DNA) in nanochannels is an effective method for achieving the elongation necessary for DNA barcoding. Recent simulations have shown that semiflexible polymers like DNA exhibit different confinement behavior than flexible polymers in intermediate channel sizes. The purpose of this study is to measure the fractional extension of lambda DNA (l-DNA) as a function of...

The need for new innovative treatments has led to the increase in nanoparticle (NP) research. NPs can improve treatment through drug delivery, cellular imaging and gene therapy. To properly use NPs for treatment, it is important to understand how NPs interact with the cellular environment. Recent research was done that compared cellular binding on cationic and anionic polystyrene NPs [1]. The r...

NNIN REU Site: Nano Research Facility, Washington University in St. Louis, St. Louis, MO NNIN REU Principal Investigator: Prof. Samuel Achilefu, Optical Radiology Laboratory, Mallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine NNIN REU Mentor: Dr. Rui Tang, Optical Radiology Laboratory, Mallinckrodt Institute of Radiology, Washington University in St. Loui...

NNIN REU Site: Nanotechnology Research Center, Georgia Institute of Technology, Atlanta, GA NNIN REU Principal Investigator: Dr. Ravi V. Bellamkonda, Neurological Biomaterials and Cancer Therapeutics Lab, Department of Biomedical Engineering, Georgia Institute of Technology NNIN REU Mentor: Dr. S.Balakrishna Pai, Neurological Biomaterials and Cancer Therapeutics Lab, Department of Biomedical En...

Functional in vitro models of neural networks are essential for uncovering the underlying cellular mechanisms by which mechanical stress induces traumatic brain injury. However, current models do not capture the connectivity and organization of the brain’s axonal tracts, limiting our ability to study how cellular dysfunction may be transmitted between distant regions of the brain. These models ...

Electrolyte-oxide-semiconductor (EOS) capacitors were fabricated to elucidate; (a) the dynamics of the ionic double layer under field-effect modulation, (b) the effect of electrolyte composition on the zero-field voltage, and (c) the role of insulator surface groups on the differential capacitance of the fluidic double layer. Surface groups, owing to their amphoteric nature, are known to regula...