Hydrogel Based Metronidazole Bioadhesive Tablet (HMBT) was prepared as a novel vaginal delivery system to achieve Controlled release of drug from the tablet for vaginal candidiasis. The highly swollen hydrogel were prepared by dissolving chitosan in acetic acid solution containing drug, followed by neutralisation with sodium hydroxide and characterized by SEM, DSC and FT-IR and evaluated for % ...

PURPOSE Bioadhesive polymers play an important role in biomedical and drug delivery applications. The aim of this study is to develop a sustained- release tablet for local application of Cetylpyridinium Chloride (CPC). This delivery system would supply the drug at an effective level for a long period of time, and thereby overcome the problem of the short retention time of CPC and could be used ...

hydrogel based metronidazole bioadhesive tablet (hmbt) was prepared as a novel vaginal delivery system to achieve controlled release of drug from the tablet for vaginal candidiasis. the highly swollen hydrogel were prepared by dissolving chitosan in acetic acid solution containing drug, followed by neutralisation with sodium hydroxide and characterized by sem, dsc and ft-ir and evaluated for % ...

Bilayer floating-bioadhesive drug delivery systems exhibiting a unique combination of floatation and bioadhesion to prolong gastric residence time were developed. Hydroxypropyl methylcellulose and sodium bicarbonate were added such that when immersed in 0.1N HCl, the tablet expands and rises to the surface and famotidine is gradually released without interference from gas bubbles. Effect of dif...

The aim of the study was to prepare and evaluate bucco-adhesive tablets of rabeprazole sodium that avoid gastric degradation and first pass metabolism, thereby increasing the drug bioavailability and onset of action. The drug, rabeprazole sodium, belongs to a class of antisecretory compounds. In the present work, different ratios of Gantrez MS 955 along with HPMC K4M were studied to give bioadh...

Purpose: To develop bioadhesive tablets of diltiazem hydrochloride with a unique combination of bioadhesion and drug release. Method: Tablets were prepared by physical blending of diltiazem hydrochloride with two polymers, viz., carbopol and hydroxylpropyl methyl cellulose in different ratio along with other excipients. A 3 central composite design was employed to optimize the formulations on t...

the present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...

The aim of the present research was to develop a bilayer tablet of venlafaxine hydrochloride for bimodal drug release. In the present investigation authors have tried to explore fenugreek mucilage (FNM) for bioadhesive sustained release layer. The attempt has been made to combine FNM with well studied bioadhesive polymers like hydroxy propyl methyl cellulose (HPMC), Carbopol, and Xanthan Gum. T...

Oromucosal delivery of drugs promotes rapid absorption and high bioavailability, with subsequent almost immediate onset of pharmacological effect. However, many oromucosal delivery systems are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. This paper introduces a new tablet system for ...

The present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...