We present a web interface which allows us to conveniently set up calculations based on the BioFET-SIM model. With the interface, the signal of a BioFET sensor can be calculated depending on its parameters, as well as the signal dependence on pH. As an illustration, two case studies are presented. In the first case, a generic peptide with opposite charges on both ends is inverted in orientation...

Current research efforts in biosensor design attempt to integrate biochemical assays with semiconductor substrates and microfluidic assemblies to realize fully integrated lab-on-chip devices. The DNA biotransistor (BioFET) is an example of such a device. The process of chemical modification of the FET and attachment of linker and probe molecules is a statistical process that can result in varia...

The developed bio-field effect transistor (BioFET) consists in nano-silver ink printed source and drain electrodes, a polymeric organic semiconductor, dielectric layer based on methyl methacrylate (MMA) and finally the reference electrode of silver-silver chloride ink. The thickness of the dielectric layer was optimized and characterized by Scanning Electron Microscopy (SEM) and by electrical m...

Specific and label-free detection of biological interactions is paramount to a plethora technological applications ranging from home-care diagnostics smart agriculture home security. The biologically-modified field-effect transistor (BioFET) promising sensing platform due its inherent signal amplification, low power, miniaturization. In the following low-cost meta-nano-channel BioFET (MNC BioFE...

Biologically sensitive field-effect transistors (BioFETs) are a promising technology for detecting pathogens, antigen-antibody complexes, and tumor markers. A BioFET is studied for a biotin-streptavidin complex. Biotin-streptavidin is used in detection and purification of various biomolecules. The link between the Angstrom scale of the chemical reaction and the micrometer scale of the field eff...

The attachment and interactions of analyte receptor biomolecules at solid-liquid interfaces are critical to development of hybrid biological-synthetic sensor devices across all size regimes. We use protein engineering approaches to engineer the sensing interface of biochemically modified field effect transistor sensors (BioFET). To date, we have deposited analyte receptor proteins on FET sensin...

BACKGROUND Ion Sensitive Field Effect Transistors (ISFETs) are one of the primitive structures for the fabrication of biosensors (BioFETs). Aiming at the optimization of the design and fabrication processes of BioFETs, the correlation between technological parameters and device electrical response can be obtained by means of an electrical device-level simulation. In this work we present a numer...