bile duct ligation (bdl) is shown to induce cholestasis-related liver function impairments as well as consequent cognitive dysfunctions (i.e. impaired learning and memory formation). this study investigates the effects of cholestasis (14, 21 and 28 days post bile duct ligation) on spatial and non-spatial novelty detection, using a non-associative task. male mice weighing 30-35 g were used. chol...

objectives to investigate the role of cgs21680, a selective adenosine a2a receptor agonist, on a bile-duct-ligated cirrhotic liver resection model in rats. methods male wistar rats were allotted into 3 groups (n = 7 per time-point): the control group, the bile duct ligation + cgs21680 group (bdl + cgs), and the bile duct ligation group (bdl). biliary cirrhosis had been previously induced by lig...

BACKGROUND Suitable experimental models of gallstone pancreatitis with systemic inflammation and mortality are limited. We developed a novel murine model of duct-ligation-induced acute pancreatitis associated with multiorgan dysfunction and severe mortality. METHODS Laparotomy was done on C57/BL6 mice followed by pancreatic duct (PD) ligation, bile duct (BD) ligation without PD ligation, or s...

Introduction: Curcumin, a natural antioxidant, has anti-inflammatory and protective effect on a large number of diseases like cancers and hepatic disorders in oxidative stress conditions by collecting free oxygen radicals and increasing intracellular glutathione. The aim of this study was to determine the effects of curcumin on the level of IL-17 and IL-10 cytokines in intrahep...

Bile duct ligation (BDL) is shown to induce cholestasis-related liver function impairments as well as consequent cognitive dysfunctions (i.e. impaired learning and memory formation). This study investigates the effects of cholestasis (14, 21 and 28 days post bile duct ligation) on spatial and nonspatial novelty detection, using a non-associative task. Male mice weighing 30-35 g were used. Chole...

BACKGROUND Liver cirrhosis is a diffuse hepatic fibrosis, and nodule formation. The transforming growth factor-beta 1 (TGF-beta 1) and interleukin-10 (IL-10) are very important cytokines in hepatic fibrogenesis. The aim of this study was to examine the relationship between the changes of the serum cytokines and morphological changes following common bile duct ligation in experimental rats. ME...

Cholangitis requires bile duct obstruction and infection. Patients with cholangitis are often more affected than those with infections that reach the liver through the portal vein. We will attempt to study the influences of (i) route of entry and (ii) presence of bile duct obstruction on hepatic infection. C57BL/6 mice received injections of Escherichia coli or lipopolysaccharide into the obstr...

Accumulation of hydrophobic bile acids during cholestasis leads to generation of oxygen free radicals in the liver. Accordingly, this study investigated whether polyphenols from green tea Camellia sinenesis, which are potent free radical scavengers, decrease hepatic injury caused by experimental cholestasis. Rats were fed a standard chow or a diet containing 0.1% polyphenolic extracts from C. s...

BACKGROUND Cognitive functions are impaired in patients with liver disease. Bile duct ligation causes cholestasis that impairs liver function. This study investigated the impact of cholestasis progression on the acquisition and retention times in the passive avoidance test and on the locomotor activity of rats. METHODS Cholestasis was induced in male Wistar rats by ligating the main bile duct...

1. The pressor and heart rate response to angiotensin II, noradrenaline, isoprenaline, tyramine and beta-phenylethylamine were examined before and after bile-duct ligation in conscious trained dogs. 2. The pressor response to angiotensin II was markedly suppressed after bile-duct ligation, although responses to noradrenaline and the indirectly acting sympathomimetic amines were only slightly re...