objectives in this study, we aimed to investigate the changes in brain lipidomics following prolonged and intermittent ischemic preconditioning. materials and methods two groups underwent bilateral common carotid artery occlusion either intermittently (for 3 continuous periods within a timeframe of 20 minutes, releasing 3 consecutive times, yielding a total of 9 minutes (intermittent bilateral ...

Background: Recent studies suggest that prolonged and intermittent bilateral common carotid artery occlusion (prolonged bilateral common carotid artery occlusion (PO) and intermittent bilateral common carotid artery occlusion, respectively) can lead to reduced ischemia brain injury in ischemic tolerance. Objectives: In this study, we aimed to investigate the changes in brain lipidomics followin...

Introduction: The aim of this study was evaluation the effects of bilateral carotid artery occlusion on cochlear oxidative stress and hearing status in rat. Methods: The rats were divided into two sets. First set used for electrophysiological recording (click and 4 kHz tone burst ABR and EcochG) at day before surgery and 1st, 4th and 7th days after surgery. Animals of second set that used for ...

one of the signifiant risk factor of ischemic stroke is carotid artery occlusion. although surgical treatment was disappointing in these patient but there is a growing reports of sucessful endovascular treatment recently. in this technical note 56 year-old man who suffered from bilateral carotid occlusion was revascularized. the penumbra thrombosuction system was applied to reduce the risk of d...

We report a case of successful endovascular treatment of bilateral carotid artery occlusion with concurrent basilar apex aneurysm. An elderly female patient with subarachnoid hemorrhage (SAH) onset was admitted to the hospital. Computed tomography (CT) and digital subtraction angiography (DSA) confirmed the presence of bilateral carotid artery occlusion with concurrent basilar apex aneurysm. Br...

BACKGROUND AND PURPOSE Evidence suggests that the protease-activated receptor-1 (PAR-1), a thrombin receptor, mediates neuronal injury in experimental cerebral ischemia. The present study investigated whether PAR-1 plays a role in brain injury after global cerebral ischemia. METHODS Adult male wild-type or PAR-1 knockout mice underwent a 20-minute bilateral common carotid artery occlusion or ...

Using monochromatic synchrotron radiation, we performed microangiography in C57BL/6J mice and investigated their vasculature after unilateral and bilateral carotid artery occlusion. Bilateral occlusion of the carotid artery was made by a ligation of the left common carotid artery followed by a ligation of the right internal carotid artery (ICA) two days later (n=12). Five days after the second ...

We studied 4 patients with bilateral carotid artery occlusion who suffered delayed TIAs in one of the occluded internal carotid or common carotid areas. Hemodynamic mechanisms were prominent in two patients, in head turning and orthostatic hypotension. In the other two cases, embolic phenomena through the homolateral external carotid collateral pathways were probable, because this artery (or th...

To enhance the consistency of the ischemic insult caused by reversible transorbital middle cerebral artery occlusion, we investigated the variability of somatosensory evoked potential amplitudes and regional cerebral blood flow in 26 anesthetized cats using four procedures to induce transient ischemia. These procedures included 60 minutes of left middle cerebral artery occlusion with or without...

objective(s):the present study investigated the effect of long-term mild cerebral hypoperfusion induced by permanent unilateral (right) common carotid artery occlusion (uco) on the dorsal hippocampal neurons in rats. materials and methods:sixty four male sprague-dawley rats aged 4 months were divided into two groups of sham and uco. these two groups were further divided into 4 sets of histopath...