one of the complications of Beta-thalasemia major is hepatobiliary disorders for example cholelithiasis(Gallstone),in this study frequency of hepatobiliary ultra sound abnormal findings in 200 patients in Kerman was investigated.among 200 patients ,11(5.5%) had gallstone.the average age of patients without  gallstone was 10.07+_4.9 years and that of patients with  gallstone was 16.1+_5 years.th...

To cite this Article Ehsani, Mohammad Ali, Hedayati-Asl, Amir Abbas, Bagheri, Alireza, Zeinali, Syrus and Rashidi, Armin(2009) 'HYDROXYUREA-INDUCED HEMATOLOGICAL RESPONSE IN TRANSFUSION-INDEPENDENT BETATHALASSEMIA INTERMEDIA: Case Series and Review of Literature', Pediatric Hematology and Oncology, 26: 8, 560 — 565 To link to this Article: DOI: 10.3109/08880010903271671 URL: http://dx.doi.org/1...

Background and Aim: Beta-thalassemia ( -thalassemia) is characterized by the reduced synthesis of the hemoglobin beta chain. Nowadays, more than 200 disease-causing mutations in beta-globin ( -globin) gene have been identified. Betathalassemia is the most common monogenic disease worldwide and one of the widespread hereditary disorders in Iran. Considering the vast spectrum of beta-thalassemia ...

Normal rabbit alveolar macrophages are engorged with large, dense inclusions which contain whorls of myelin figures, suggesting an exogenous source of polar lipids in their diet. One contributory source of such lipids is surfactant, since macrophages were seen ingesting tubular myelin and vacuoles containing remnants of it were found in the cytoplasm. Thus, as indicated previously in kinetic st...

Reduction of tissues with sodium cyanoborohydride at pH7.4 gave results identical with those obtained by KBH4 treatment. On reduction with sodium cyanoborohydride at pH 4.4, however, a previously undetected basic compound was formed and was identified by mass spectrometry and chemical degradation techniques as dihydrohydroxymerodesmosine. Histidino-hydroxymerodesmosine was not present, and furt...

Thalassemias are a heterogeneous group of disorders of hemoglobin synthesis which are characterized by the absence or reduced output of one or more globin chains of hemoglobin. This disease is a public health problem in Malaysia and can be confusing for the patients and the doctors as the picture varies from one patient to another. About 4.5% of the people in Malaysia are heterozygous carriers ...

Aim of the Study: To assess maternal and fetal outcome in pregnant patients with Beta-thalassemia major. Material and Methods: A prospective study of pregnancy outcome of women with beta-thalassemia major admitted to the High Risk Pregnancy Unit, Department of Obstetrics and Gynecology, Kasr Al Aini hospital over the period of March 2010 to October 2013. Results: A total of 22 pregnant patients...