نتایج جستجو برای: Beta2 toxin

تعداد نتایج: 55234  

Journal: :archives of razi institute 2016
m. esmaeilizad f. tekyei a.r. jabbari r. pilehchian langroudi

clostridium perfringens is an important cause of enteric diseases in both human and animals. the bacteria produce several toxins which play key roles in the pathogenesis of diseases and are classified into five toxin types, on the basis of the differential production of alpha, beta, epsilon and iota toxins. in this study a single pcr assay was developed and used for detection of cpb2 gene to id...

Journal: :Infection and immunity 2005
B Helen Jost Stephen J Billington Hien T Trinh Dawn M Bueschel J Glenn Songer

Beta2-toxin, encoded by cpb2, is implicated in the pathogenesis of Clostridium perfringens enteritis. However, cpb2 genes from nonporcine C. perfringens isolates were not always expressed, at least in vitro. Nucleotide sequencing identified atypical cpb2 genes with 70.2 to 70.7% DNA identity to previously identified (consensus) cpb2. Atypical beta2-toxin displayed 62.3% identity and 80.4% simil...

A.R. Jabbari, F. Tekyei M. Esmaeilizad R. Pilehchian Langroudi

Clostridium perfringens is an important cause of enteric diseases in both human and animals. The bacteria produce several toxins which play key roles in the pathogenesis of diseases and are classified into five toxin types, on the basis of the differential production of Alpha, Beta, Epsilon and Iota toxins. In this study a single PCR assay was developed and used for detection of cpb2 gene to id...

Journal: :Veterinary microbiology 2002
C Manteca G Daube T Jauniaux A Linden V Pirson J Detilleux A Ginter P Coppe A Kaeckenbeeck J G Mainil

Non-enterotoxigenic type A Clostridium perfringens are associated with bovine enterotoxaemia, but the alpha toxin is not regarded as responsible for the production of typical lesions of necrotic and haemorrhagic enteritis. The purpose of this study was to investigate the putative role of the more recently described beta2 toxin. Seven hundred and fourteen non-enterotoxigenic type A C. perfringen...

Journal: :Investigative ophthalmology & visual science 2000
S Hoffmann R Masood Y Zhang S He S J Ryan P Gill D R Hinton

PURPOSE To determine the sensitivity of retinal pigment epithelial (RPE) cells to a vascular endothelial growth factor (VEGF) chimeric toxin. METHODS A targeted toxin was developed using recombinant methods to fuse VEGF165 to the diphtheria toxin (DT) translocation and enzymatic domain (DT390-VEGF165). Human RPE cells, choroidal endothelial cells (CECs), and scleral fibroblasts were isolated,...

Journal: :iranian journal of microbiology 0
jamshid razmyar department of clinical sciences, faculty of veterinary medicine, ferdowsi university of mashhad, mashhad, iran. gholam-ali kalidari department of clinical sciences, faculty of veterinary medicine, ferdowsi university of mashhad, mashhad, iran. ali tolooe graduated dvm, dvsc in poultry health & diseases, university of tehran, tehran, iran. mehrnaz rad department of pathobiology, faculty of veterinary medicine, ferdowsi university of mashhad, mashhad, iran. ahmad-reza movassaghi department of pathobiology, faculty of veterinary medicine, ferdowsi university of mashhad, mashhad, iran.

background and objectives: clostridium perfringens is more prevalent type of clostridia genus isolated from the intestinal tract of ostrich ( struthio camelus ). necrotic enteritis (ne) is a potentially fatal gastrointestinal (gi) disease of poultry and other avian species, which produces marked destruction of intestinal lining in digestive tract caused by c. perfringens . pathogenicity and les...

Journal: :Molecular pharmacology 2003
Catherine Pavoine Niloufar Behforouz Chantal Gauthier Sabine Le Gouvello Francoise Roudot-Thoraval Catherine Rucker Martin Andre Pawlak Chloe Feral Nicole Defer Remi Houel Sandrine Magne Aissata Amadou Daniel Loisance Philippe Duvaldestin Francoise Pecker

We have recently established that enhancement of intracellular calcium cycling and contraction in response to beta2-adrenergic receptor (beta2-AR) stimulation exclusively relies on the activation of the cytosolic phospholipase A2 (cPLA2) and arachidonic acid production, via a pertussis toxin-sensitive G protein (possibly Gi), in embryonic chick cardiomyocytes. We aimed to investigate the releva...

2011

Clostridium perfringens is an important pathogen in both human and veterinary medicine. Necrotic enteritis (NE) is the most clinically dramatic bacterial enteric disease of poultry induced by C. perfringens. The pathogenicity of this bacterium is associated with the production of extracellular toxins produced by some of its strains, such as beta2 toxin. The exact role of beta2 toxin in NE patho...

2012
Masahiro Nagahama Masataka Oda Keiko Kobayashi

Clostridium perfringens type C strains that produce various toxins cause hemorrhagic noxious ulceration or mucousal necrosis of the small intestine in humans, pigs, cattle and chickens (Sakurai et al. 1997, Sakurai and Nagahama 2006). In humans, the bacteria cause necrotic enteritis, which is termed “pig-bel” (Sakurai and Nagahama 2006). C. perfringens has been classified into five types, A to ...

Journal: :Journal of the American Veterinary Medical Association 2005
Anita C Dennison David C Van Metre Paul S Morley Robert J Callan Emily C Plampin R P Ellis

OBJECTIVE To compare the frequency of isolation, genotypes, and in vivo production of major lethal toxins of Clostridium perfringens in adult dairy cows affected with hemorrhagic bowel syndrome (HBS) versus left-displaced abomasum (LDA). DESIGN Case-control study. ANIMALS 10 adult dairy cattle with HBS (cases) and 10 adult dairy cattle with LDA matched with cases by herd of origin (controls...

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