abstract background prevalence of hereditary blood diseases such as sickle cell anemia, sickle thalassemia and thalassemia major are high in khuzestan province. sickle cell anemia and beta-thalassemia are predominantly common in iranian arabs. pulmonary complications account for a large proportion of morbidity and mortality in patients with and sickle cell disease. periodic lung function assess...

in spite of their key role in various immunological processes occurring in the endometrium, t cells- especially + subtype- residing in this mucosal tissue, have not been extensively explored. we present here the profile of expressed genes for variable region of chain of t cell receptor (tcr) in normal endometrium as compared to peripheral blood. samples from endometrium were taken from norm...

peripheral blood t lymphocytes and their subsets were studied in 31 patients with beta thalassemia major (age 2-12years) and compared with 14 age-arid sex-matched healthy controls. three monoclonal antibodies (anti-cd3, anti cd-f, unti-cds) were simultaneously applied for detection of th (cd3-, cd4^), tsk (cd3+, cd8+) and th/ts ratio by flow-cytometry respectively. the results of this study sho...

conclusions in iran, hsct has been successfully adapted in routine clinical care. recently, new methods such as double cord blood and haploidentical transplantation have been used to treat many life-threatening diseases. results about 78.2% of the patients (2530 of 3237) remained alive between one to 211 months after stem cell transplantation. nearly, 21.8% (707) of our patients died after stem...

vanadium salts have been suggested as a possible therapeutic agent for the treatment of diabetes. the aim of the present study was to clarify histological and immunohistochemical changes that occur in the pancreatic beta (β) cells of vanadyl sulphate (vs)-treated streptozotocin (stz) induced diabetic rats. male wi star rats were made diabetic by injecting a single intravenous dose of stz (40 mg...

from 1996 to 2002, fifty three patients with major beta-thalassemia received allogeneic peripheral blood stem cell trans plantation (pbsct). median age was 6 years .twenty two were class i, 17 class ii and 14 class iii. all of the donors were hla-identical. conditioning regimen for class i and ii patients consisted of cyclophosphamide (cy) 50 mg/kg/day for 4 days + busulfan (bu) 3.5 mg/kg for 4...

the restriction enzyme ava ii detects the base change of the intervening sequence ii (ivs ii) which is used as one of the markers of β-globin gene polymorphism. this study was conducted to determine the frequency of the ava ii site on the β-globin gene among normal people and patients with sickle cell syndrome (scs) in iran. dna fragments containing the ivs ii region of the β-globin gene from 3...

objective(s):in this study the effect of oral administration of honey on serum glucose, lipids, stress oxidative markers, and morphology of langerhans islets in noise induced hyperglycemic rats was investigated. materials and methods: male wistar rats were divided into control, hyperglycemic, honey treated control, and honey treated hyperglycemic groups. for induction of hyperglycemia, noise st...

transforming growth factor beta (tgf-b) is a mediator released by nearly all cell types. it has suppression activity on the immune system, but exactly how this effect is carried out is not clear. previous experiments showed that igg interacts with or carriers active tgf-b, that could suppresses cytotoxic t-cell responses to an immunogenic tumor in mice. since t cell receptor (tcr) has structura...