Coumarins are a family of compounds that have been studied extensively for their practical applications, as textile dyes, optical brighteners, laser dyes, sensitisers in phototherapy, biological labels. Coumarin derivatives have been also used in making fluorogenic enzyme substrates. Disperse dyes containing an electron-donating group, such as N,N-diethylamino, and an heterocyclic residue in po...

Our previously synthesized 37 compounds, which are 2,5,6-substituted benzoxazole, benzimidazole, benzothiazole, and oxazolo(4,5-b)pyridine derivatives, were tested for their eukaryotic DNA topoisomerase II inhibitory activity in cell free system and 28 were found to inhibit the topoisomerase II at an initial concentration of 100 microg/ml. After further testing at a lower range of concentration...

A highly practical procedure for preparing benzoxazole-2-ones, benzothiazole-2-ones and its 2-thione derivatives using ethylchloroformate and carbon disulfide and the corresponding aminophenols and aminothiophenols as the starting materials in one-pot protocol is presented. The yields vary from good to excellent, the conditions are mild, and the use of toxic and harmful chemicals is avoided. An...

The synthesis of visnaginone-oxime (2 a) and khellinone-oxime (2 b) is reported. Beckmann rearrangement of 2 a and 2b using different cyclising agents was studied. Structure assignement for the produced benzoxazole derivatives and benzisoxazole derivatives was confirmed by chemical and spectral evidences. Utilization of visnaginone (la) and khellinone (lb) for the synthesis of new furoflavone d...

The arylation of mono-, di- and tetra-meso-bromophenyl-substituted porphyrins with the heteroarenes containing "acidic" C-H bonds, such as benzoxazole, benzothiazole and N-methylimidazole was studied in the presence of three alternative catalytic systems: Pd(dba)2/DavePhos/Cs2CO3, Pd(PPh3)4/PivOH/K2CO3 and Pd(OAc)2/Cu(OAc)2/PPh3/K2CO3. The first catalytic system was found to be successful in th...

Herein method for the synthesis of substituted 1,2benzoxazolone (8a-f) and 3-chloro-1,2-benzoxazole (9a-f) derivatives has been described. A new scheme has been adapted for the construction of 1,2benzoxazole ring from salicylic acid and its derivatives which leads to the formation of series of 5,6 and 7 substituted title compounds. Synthesized compounds were characterized by IR, 1 H-NMR and Mas...

Solvatochromic probes are often used in biophysical studies to obtain information about polarity of the microenvironment. As there is not much natural fluorophores with such properties, there is still need for new synthetic compounds such as 3-(2-benzoxazol-5-yl)alanine derivatives. Among this group of non-proteinogenic fluorescent amino acids especially interesting are 3-[2-(4-aminophenyl)benz...

The endeavor of this study was to design, synthesize and investigate the in vivo anti-inflammatory and analgesic activity of some novel 2-(2-(benzo[d]oxazol-2-yl) phenylamino)-N-(substituted phenyl) acetamide (2A-2F) derivatives. 2-(2-aminophenyl) benzoxazole (D1) was synthesized by the condensation of anthranilic acid with starting material 2-aminophenol in the existence of poly phosphoric aci...