benzofuran as an important heterocyclic compound is extensively found in natural products as well as synthetic materials. since benzofuran drivatives display a diverse array of pharmacological activities, an interest in developing new biologically active agents from benzofuran is still under consideration. this review highlights recent findings on biological activities of benzofuran derivatives...

Chalcones are very well known natural as well as synthetic compounds associated with diverse set of pharmacological activities. They have the potential to be developed as lead compounds for the discovery of antioxidant, anti-inflammatory and anticancer agents. Naturally occurring and synthetic chalcone compounds have shown safety profiles in clinical trials. To study impact of substitutions on ...

Chalcones exhibit chemopreventive and antitumor effects. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a naturally occurring anticancer agent that induces apoptosis in cancer cells and is not toxic to normal cells. We examined the cytotoxic and apoptotic effect of five chalcones in combination with TRAIL on prostate cancer cells. The cytotoxicity was evaluated by the MTT an...

The kinetic reaction of the benzofuran–stilbene hybrid compound 5-(2-(2-(4-hydroxyphenyl)benzofuran-5-yl)vinyl)benzene-1,3-diol captures HOO? free radical.

Abstract Three different reactions were explored leading to the synthesis of various benzofurans. All took place under AcOH catalysis in a one-pot manner. As result, benzoquinone derivatives underwent heteroannulation with either itself or cyclohexanones produce furanylidene-benzofuran benzofuran structures, respectively.

Several obstacles are encountered in conventional chemotherapy, such as drug toxicity and poor stability. Nanotechnology is envisioned as a strategy to overcome these effects and to improve anticancer therapy. Nanoemulsions comprise submicron emulsions composed of biocompatible lipids, and present a large surface area revealing interesting physical properties. Chalcones are flavonoid precursors...

The synthesis of deoxy-Breslow intermediates in their oxidized form has been developed via the reaction of N-heterocyclic carbenes (NHCs) with chalcones. Moreover, the initial tetrahedral adduct formed from the 1,4-addition of NHCs to chalcones is also isolated.

In this study the chemistry of chalcones has generated intensive scientific interest due to their biological and industrial applications. Chalcones are natural biocides and are well known intermediates in the synthesis of heterocyclic compounds exhibiting various biological activities. Chalcones and their derivatives possess some interesting biological properties such as antibacterial, antifung...

Histone deacetylase enzymes (HDACs) are emerging as a promising biological target for cancer and inflammation. Using a fluorescence assay, we tested the in vitro HDAC inhibitory activity of twenty-one natural chalcones, a widespread group of natural products with well-known anti-inflammatory and antitumor effects. Since HDACs regulate the expressi...