benzofuran as an important heterocyclic compound is extensively found in natural products as well as synthetic materials. since benzofuran drivatives display a diverse array of pharmacological activities, an interest in developing new biologically active agents from benzofuran is still under consideration. this review highlights recent findings on biological activities of benzofuran derivatives...

The kinetic reaction of the benzofuran–stilbene hybrid compound 5-(2-(2-(4-hydroxyphenyl)benzofuran-5-yl)vinyl)benzene-1,3-diol captures HOO? free radical.

Abstract Three different reactions were explored leading to the synthesis of various benzofurans. All took place under AcOH catalysis in a one-pot manner. As result, benzoquinone derivatives underwent heteroannulation with either itself or cyclohexanones produce furanylidene-benzofuran benzofuran structures, respectively.

During a synthesis of coumarins to obtain new candidates for treating Alzheimer's Disease (AD), an unusual rearrangement of a benzopyran group to a benzofuran group occurred, offering a novel synthesis pathway of these benzofuran derivatives. The possible mechanism of the novel rearrangement was also discussed. All of the benzofuran derivatives have weak anti-AChE activities compared with the r...

In the title compound, C(16)H(12)O(4), the 1-benzofuran-one unit is in a planar conformation [C-C-C-C = 179.69 (12)°]. The conformation around the C=C double bond [1.3370 (17) Å] is Z. In the crystal, the mol-ecules are stabilized by O-H⋯O (running parallel to the bc plane) and C-H⋯O hydrogen bonds.

In the title compound, C(20)H(17)NO(4), the double bond of the acrylonitrile group separating the 1-benzofuran moiety from the 3,4,5-trimeth-oxy-phenyl ring has Z geometry. The 1-benzofuran groups are π-π stacked with inversion-related counterparts such that the furan ring centroid-centroid distance is 3.804 (5) Å. The dihedral angle between the planes of the trimeth-oxy-phenyl ring and the acr...

In the title compound, C(21)H(15)FOS, the 4-fluoro-phenyl ring is rotated out of the benzofuran plane, making a dihedral angle of 24.3 (1)°. The dihedral angle between the phenyl ring and the benzofuran plane is 28.3 (1)°. The crystal structure may be stabilized by two very weak aromatic π-π inter-actions between the furan and the benzene rings of neighbouring benzofuran systems; the centroid-c...

The current work reports an organocatalytic strategy for the asymmetric catalysis of chiral benzofuran-2(3H)-ones bearing 3-position all-carbon quaternary stereocenters. Accordingly, highly enantioselective Michael addition reactions of 3-substituted benzofuran-2(3H)-ones to nitroolefins have been developed by utilizing a bifunctional tertiary-amine thiourea catalyst. The reactions accommodate ...

In the title compound, C(15)H(10)BrFO(2)S, the O atom and the methyl group of the methyl-sulfinyl substituent lie on opposite sides of the plane through the benzofuran fragment. The 4-bromo-phenyl ring is rotated out of the benzofuran plane [dihedral angle = 38.98 (8)°], while the structure is stabilized by an inter-molecular C-H⋯O hydrogen bond and a Br⋯O halogen bond [3.036 (2) Å] and has an ...

Chem. Abstr. Serv. Reg. No.: 126-07-8 Deleted CAS Nos: 8027-03-0; 8055-10-5; 3426-54-8; 11103-62-1; 24659-79-8 Chem. Abstr. Name: (1′S,6′R)-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione IUPAC Systematic Name: 7-Chloro-2′,4,6-trimethoxy-6′β-methylspiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione Synonyms: (2S,4′R)-7-Chloro-2′,4,6-trimethoxy-4′-methyl...