Box and Behnken (1960) constructed 10 three-level, second-order designs, while their 1958 technical report contained seven additional designs. This series of designs is based on combining 2 or 2 designs in different subsets of the t factors, with k < t. The subsets of size k were determined using balanced (or partially balanced) incomplete block designs. This present article offers additional B...

Response surface methodology was engaged for the optimization of diverse nutritional and physical parameters for laccase production by Streptomyces chartreusis strain NBRC 12753 in the submerged fermentation process. Screening of production parameters was executed using Plackett–Burman design and the variables with statistically momentous effects on laccase production were recognized. Variables...

Box-Behnken designs (Box and Behnken, 1958, 1960) form a very popular class of 3-level second-order designs when the number of factors is small, typically, seven or less. For larger number of factors these designs are not so popular because then, these designs require a large number of runs. This paper provides a catalog of 3-level second-order designs for 5-11 factors with run sizes ≤ 100. All...

A statistical programme using Box-Behnken design, which applies a response optimization algorithm, was used to calculate and optimize simultaneously the lactic acid extraction by emulsion liquid membrane (ELM) in a mixed flow reactor. A 3-level Box-Behnken design with seven variables i.e. lactic acid concentration, internal reagent concentration, Alamine 336 fraction in oleyl alcohol, stirring ...

Using Dachengqi Tang (DCQT) as a model, high performance liquid chromatography (HPLC) fingerprints were applied to optimize machine extracting process with the Box-Behnken experimental design. HPLC fingerprints were carried out to investigate the chemical ingredients of DCQT; synthetic weighing method based on analytic hierarchy process (AHP) and criteria importance through intercriteria correl...

Optimization of protein extraction using silk cocoon was carried out by the design of experiment (DOE) to obtain the response surface methodology ( RSM ). Box-Behnken rotatable design was used to create an experimental program to provide data to model the effects of various factors on protein extraction efficiency. The variables chosen were sodium carbonate concentration ( 1 X ), Lithum bromide...

For all industrial processes, modelling, optimisation and control are the keys to enhance productivity and ensure product quality. In the current study, the optimization of process parameters for improving the conversion of isoeugenol to vanillin by Psychrobacter sp. CSW4 was investigated by means of Taguchi approach and Box-Behnken statistical design under resting cell conditions. Taguchi desi...

The objective of this work was design, characterization, and optimization of controlled drug delivery system containing antibiotic drug/s. Osmotic drug delivery system was chosen as controlled drug delivery system. The porous osmotic pump tablets were designed using Plackett-Burman and Box-Behnken factorial design to find out the best formulation. For screening of three categories of polymers, ...

This work provides an optimized extraction approach intended to maximize the recovery of dihydromyricetin (DHM) from Chinese vine tea (Ampelopsis grossedentata) leaves. The presented work adopts a Box-Behnken design as a response surface methodology to understand the role and influence of specific extraction parameters including: time, temperature, and solvent composition/ethanol (%) on DHM fin...

Essential oil components were extracted from Lavandula angustifolia (Lavender) flowers using pressurized fluid extraction (PFE). A Box-Behnken design was used to optimize the effective extraction variables. The chemical composition of extracted samples was analyzed by gas chromatograph-flame ionization detector column. For achieving maximum % extraction yield the temperature, pressure, and dyna...