نتایج جستجو برای: Bcl-xL
تعداد نتایج: 26389 فیلتر نتایج به سال:
ischemia-reperfusion injury is the tissue damage happened when blood supply returns to the tissue after a period of ischemia or shortage of oxygen. this brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. the aim of this study is investigating the effect of hydroalcoholic extract of cyperus rotundus l. on the expression of the bcl-x1 an...
چکیده زمینه و هدف: دیابت قندی یک اختلال مزمن متابولیک همراه با افزایش قند خون می باشد که به طور نامطلوبی هر دو سیستم عصبی مرکزی و محیطی را درگیر می کند. از آن جا که ژن های خانواده ی bcl-2 نقش مهمی در تنظیم آپوپتوز دارند، هدف از مطالعه ی حاضر بررسی اثرات انسولین و اسیداسکوربیک بر بیان ژن های خانواده ی bcl-2 نظیر bax (القا کننده ی آپوپتوز)، bcl-2 و bcl-xl (مهارکننده ی آپوپتوز) در هیپوکامپ موش های...
Introduction: Memory impairment is one of the complications of diabetes which may accompany with changes in expression of apoptotic and antiapoptotic genes. The aim of the present study was the evaluation of intra-hippocampal injection of aminoguanidine (AG), as an antioxidant and inducible nitric oxide synthase inhibitor, on passive avoidance memory and Bcl-2 family genes expression in diab...
ABSTRACT
 The purpose of this study was to isolate and test its cytotoxic activity starting from extract fraction compound, then carried out molecular docking confirm the potential biological ligands (vocangine, vobtusine, vobtusine lactone) against inhibition proteins (Bcl-2, Bcl-xL, Mcl-1), activation protein Bax apoptotic execution Caspase-3. This research is an experimental quantitativ...
زمینه و هدف: دیابت شیرین با نقص در اعمال شناختی از جمله اختلال در یادگیری و حافظه همراه است. ارزیابی اثر تزریق داخل هیپوکامپی آمینوگوانیدین با دوز های g/rat µ 90 و10 بر حافظه اجتنابی غیرفعال و بیان ژن های خانواده bcl-2 در موش های صحرایی نر دیابتی اهداف این مطالعه را تشکیل می دهد. روش بررسی: موش های صحرایی به 7 گروه تقسیم شدند. گروه های دیابتی با تزریق داخل صفاقی mg/kg 50 استرپتوزوسین دیابتی شدن...
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unknown etiology affecting over 1% the US population. Deep epidermal infiltrative cysts and tunnels characteristic develop in intertriginous skin, with mixed immune infiltrate present inflamed regions, dominated by B T cells, but also including myeloid cells. Recent studies show progressive increase cells plasma as HS lesio...
conclusions these results suggest that toxins induce inflammatory responses, particularly through expression of chemokine. recombinant stx and native toxin induced apoptosis by balancing between different pro- and anti-apoptotic bcl-2 family-factors in epithelial cells. in this study, for the first time, recombinant and native stx induction of apoptotic factors and stimulation of immune respons...
Background and objective: Diabetes is a metabolic disorder that has been shown to adversely affect both the central and peripheral nervous system by increasing basal neuronal apoptosis. Since Bcl-2 protein family is considered to play a key role in the regulation of apoptosis, in the present study we have examined the effects of insulin and ascorbic acid on expression of Bcl-2 family members in...
The effect of Bcl-xL upon the developmental death of T cells was assessed by generating transgenic mice that expressed Bcl-xL within all thymocyte subsets. Bcl-xL protected thymocytes from a variety of apoptotic stimuli, including gamma irradiation, glucocorticoids, and anti-CD3 treatment. Bcl-xL altered thymocyte maturation, resulting in increased numbers of CD3int/hi and CD4-8+ thymocytes. Ov...
Anti-apoptotic B-cell lymphoma 2 (Bcl-2) family members target several intracellular Ca(2+)-transport systems. Bcl-2, via its N-terminal Bcl-2 homology (BH) 4 domain, inhibits both inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs), while Bcl-XL, likely independently of its BH4 domain, sensitizes IP3Rs. It remains elusive whether Bcl-XL can also target and modulate Ry...
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