Background and aims: Cutaneous leishmaniasis (CL) is still a health problem in the world, including Iran where its cases have significantly increased in recent years. The objective of this study was to assess a new focus of anthroponotic CL in rural communities after the earthquake in Bam district. Method: After the report of the provincial health authorities, this study has been carried out...

Background & Aims: Cutaneous leishmaniasis (CL) has been endemic in Bam district for many years and several epidemics have already occurred. Following a silent period, another outbreak of CL occurred after the earthquake in 2003. This study was performed to find the trend of CL during 20 years (1988-2007) in Bam district. Methods: In a retrospective study, data of 29395 CL patients were col...

BACKGROUND Cutaneous leishmaniasis (CL) remains a serious public health concern in Kerman Province, eastern Iran. This study was aimed to conduct a comprehensive review and highlights various aspects of CL in the province of Kerman. METHODS This article mainly focuses on the studies published in the past 26 years on CL in the province. Current data for the present status were obtained through...

S FOR INTERNATIONAL CONFERENCE ON THE DEMOGRAPHY OF DISASTERS: IMPLICATIONS FOR FUTURE POLICY ON DEVELOPMENT AND RESILIENCE Mohammad Jalal Abbasi-Shavazi and Meimanat Hosseini-Chavoshi Title: Demographic Consequences of the 2003 Bam Earthquake in Iran Iran is a seismically active country crossed by several major fault lines resulting in frequent and often destructive earthquakes. This paper aim...

Background & Aims: Cutaneous leishmaniasis (CL) is a health problem in the world, including Iran. The objective of this study was to assess the epidemiology of CL and determination of the causative parasite species in the city and suburb of Mohammadabad, Jiroft district. Method: This descriptive and cross-sectional study was performed in census manner. Diagnosis was based on direct smear micros...

BACKGROUND Leishmania tropica is a genetically divergent species. Amplification of entire internal transcribed spacer (ITS) region of L. tropica isolates obtained from Bam district, one of the well known focus of anthroponotic cutaneous leishmaniasis (ACL) in Iran, revealed a double-band pattern in agarose gel electrophoresis. This study explains how this pattern occurs. METHODS Twenty seven ...

The transition from a Drosophila ovarian germline stem cell (GSC) to its differentiated daughter cell, the cystoblast, is controlled by both niche signals and intrinsic factors. piwi and pumilio (pum) are essential for GSC self-renewal, whereas bag-of-marbles (bam) is required for cystoblast differentiation. We demonstrate that Piwi and Bam proteins are expressed independently of each other in ...

The Drosophila germ-cell lineage has emerged as a remarkable system for identifying genes required for changes in cell fate from stem cells into more specialized cells. Previous work indicates that bam expression is necessary for cystoblast differentiation; bam mutant germ cells fail to differentiate, but instead proliferate like stem cells. This paper reports that ectopic expression of bam is ...

Bag of Marbles (Bam) is a stem cell differentiation factor in the Drosophila germ line. Here, we demonstrate that Bam has a crucial function in the lymph gland, the tissue that orchestrates the second phase of Drosophila hematopoiesis. In bam mutant larvae, depletion of hematopoietic progenitors is observed, coupled with prodigious production of differentiated hemocytes. Conversely, forced expr...

Bag of Marbles (Bam) is known to function as a positive regulator of hematopoietic progenitor maintenance in the lymph gland blood cell-forming organ during Drosophila hematopoiesis. Here, we demonstrate a key function for Bam in cells of the lymph gland posterior signaling center (PSC), a cellular domain proven to function as a hematopoietic niche. Bam is expressed in PSC cells, and gene loss-...