BACKGROUND AND THE PURPOSE OF THE STUDY Baclofen, a centrally acting skeletal muscle relaxant, is indicated in the long-term treatment of spasticity. It is difficult to formulate baclofen sustained release dosage forms because its absorption on arrival to colon (or even before) is low or nonexistent. In the present investigation efforts were made to improve the bioavailability of baclofen by in...

Baclofen is a gamma-aminobutyric acid type B receptor agonist used as an anti-craving agent for treatment of alcohol dependence. It has gained popularity in the recent times because it is well tolerated even in patients with hepatic impairments. Herein we are summarizing the latest literature about baclofen induced hypomania and are reporting a case of baclofen abuse because of its mood elevati...

Baclofen is the P-chlorophenyl derivative of gamma-aminobutyric acid (GABA) derivative with an antispasmodic action and is used as a central acting muscle relaxant. GABA is a suppressive neurotransmitter widely distributed in the peripheral and central nervous systems (1). Baclofen [3-(p-Chlorophenyl)4-aminobutanoic acid], is a GABA B agonist. Baclofen has both presynaptic and post synaptic act...

The aim of the present investigation was to prepare & evaluate bilayer floating tablet of Baclofen. In which one layer was made up of immediate release layer to provide loading dose, while another layer was made up of floating layer of BCF to provide maintenance dose. The focus of present work was to prepare and evaluate bilayer floating tablet of Baclofen to increase residence time in stomach ...

Background.  Many mechanisms are involved in pain transmission in the spinal cord.  Therefore, combination of drugs acting on different kinds of mechanisms might be useful for analgesia.  We investigated the interaction betweenγ-aminobutyric acid （GABA）B receptor agonist, baclofen, and N-methyl-D-aspartate （NMDA） receptor antagonist, AP-5, orα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ...

The relative bioavailability of the test (generic) product 2 × 25 mg baclofen tablets, with respect to the reference product, Lioresal® 2 × 25 mg tablets (baclofen; Squibb) was determined in a single-blind, single dose, randomised, crossover study. The mean values for the variable Cmax were 737.6 ng/ml for the reference and 739.5 ng/ml for the test product. The mean values for the variable AUC ...

Abstract Introduction Baclofen is a gamma-aminobutyric acid-B agonist that targets neurons in the spinal cord and brain. It has skeletal muscle-relaxant properties FDA approved to treat spasticity from injury (SCI), multiple sclerosis, or traumatic brain injury. Off label use includes treatment of alcohol disorder, hiccups, muscle spasms. A rare respiratory side effect baclofen apnea, with repo...

The relative bioavailability of the test (generic) product 2 × 25 mg baclofen tablets, with respect to the reference product, Lioresal® 2 × 25 mg tablets (baclofen; Squibb) was determined in a single-blind, single dose, randomised, crossover study. The mean values for the variable Cmax were 737.6 ng/ml for the reference and 739.5 ng/ml for the test product. The mean values for the variable AUC ...