We have identified the gene bric à brac and show that it is required for pattern formation along the proximal-distal axis of the leg and antenna of Drosophila. In bric à brac mutant legs, the bristle pattern of the three central tarsal segments is transformed towards the pattern of the most proximal tarsal segment. In addition, bric à brac mutant legs and antennae have segmentation defects. bri...

The insect antenna and leg are considered homologous structures, likely to have arisen via duplication and divergence from an ancestral limb. Consistent with this, the antenna and leg are derived from primordia with similar developmental potentials. Nonetheless, the adult structures differ in both form and function. In Drosophila, one conspicuous morphological difference is that the antenna has...

W. Gao, H. Zhu, K. Giovanello, K. Smith, D. Shen, J. Gilmore, and W. Lin Department of Biomedical Engineering, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States, Department of Biostatistics and BRIC, University of North Carolina-Chapel Hill, Department of Psychology and BRIC, University of North Carolina-Chapel Hill, Department of Radiology, University of Nort...

W. Gao, H. Zhu, K. Giovanello, K. Smith, D. Shen, J. Gilmore, and W. Lin Department of Biomedical Engineering, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States, Department of Biostatistics and BRIC, University of North Carolina-Chapel Hill, Department of Psychology and BRIC, University of North Carolina-Chapel Hill, Department of Radiology, University of Nort...

W. Gao, H. Zhu, K. Giovanello, K. Smith, D. Shen, J. Gilmore, and W. Lin Department of Biomedical Engineering, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States, Department of Biostatistics and BRIC, University of North Carolina-Chapel Hill, Department of Psychology and BRIC, University of North Carolina-Chapel Hill, Department of Radiology, University of Nort...

Purpose – The purpose of this paper is to analyze the status of corporate social responsibility (CSR) communications in Brazil, Russia, India, and China (BRIC) nations. The four countries are among the biggest emerging markets, forecasted to have increasing influence in economic and political spheres. How these countries manage their corporate communication in regards to CSR is, thus, the focus...

Benign recurrent intrahepatic cholestasis (BRIC) is a peculiar familial disease caused by mutations of the genes encoding hepatocanalicular flippase for phosphatidylserine (ATP8B1; BRIC type 1) or the bile salt export pump (ABCB11; BRIC type 2). Here, we report on a patient with nasobiliary drainage-refractory BRIC type 2 who improved under plasma separation and anion absorption therapy. We als...

Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomal recessive inherited disorder characterized by multiple recurrent episodes of severe cholestatic jaundice without obstruction of extrahepatic bile duct. We present the case of a 7-year-old boy with BRIC confirmed by mutation analysis in the ATP8B1 gene and typical clinical manifestation. Despite inheritance of BRIC, we detected...

We have used synthetic peptides to study the location of the amino acid sequences in the human erythrocyte anion transport protein (band 3) which are recognized by four murine monoclonal antibodies, BRIC 130, 132, 154 and 155. These antibodies are known to react with epitopes in the protein which are on the cytoplasmic side of the membrane. The results suggest that the amino acid residues impor...

Introduction: Benign recurrent intrahepatic cholestasis (BRIC) is a rare genetic disorder characterized by episodes of cholestatic jaundice that may last days to months. It can start at any age, but often in first decade life. The syndrome does not lead progressive liver dysfunction and cirrhosis. Between patients have no symptoms laboratory levels are within the norms. exact mechanism BRIC man...