To examine the effects of exposure to manganese (Mn) on the cellular and humoral immune system in men, T lymphocyte subpopulations, B (CD19+) lymphocytes, natural killer (NK) cells, and serum immunoglobulins (i.e., IgG, IgA and IgM) together with total T (CD3+) lymphocytes and total lymphocytes were measured in blood samples from 21 welders mainly exposed to Mn fume with blood Mn (BMn) concentr...

Anti-PARP drugs were initially developed as catalytic inhibitors to block the repair of DNA single-strand breaks. We recently reported that several PARP inhibitors have an additional cytotoxic mechanism by trapping PARP-DNA complexes, and that both olaparib and niraparib act as PARP poisons at pharmacologic concentrations. Therefore, we have proposed that PARP inhibitors should be evaluated bas...

Bone Marrow Necrosis (BMN) is regarded as a rare entity in the aspirates and the trephine biopsies which are obtained from living patients and it is a rare antemortem diagnosis. Usually, BMN is associated with a poor prognosis and it has a 90% association with malignancies (mainly haematological). Its other causes include infections, drugs and other non malignant haematological causes. BMN whic...

AIMS To report the first eight bone marrow necrosis (BMN) cases related to paracoccidioidomycosis (PCM) from patient autopsies with well-documented bone marrow (BM) histology and cytology. METHODS AND RESULTS A retrospective evaluation was performed on BM specimens from eight autopsied patients from Botucatu University Hospital with PCM-related BMN. Relevant BMN literature was searched and an...

We previously established two silkworm cell lines, BmN-SWU1 and BmN-SWU2, from Bombyx mori ovaries. BmN-SWU1 cells are susceptible while BmN-SWU2 cells are highly resistant to BmNPV infection. Interestingly, we found that the entry of BmNPV into BmN-SWU2 cells was largely inhibited. To explore the mechanism of this inhibition, in this study we used isobaric tags for relative and absolute quanti...

We previously established and characterized two insect cell lines (BmN-SWU1 and BmN-SWU2) from Bombyx mori ovaries. Here, we examined their differential susceptibilities to Bombyx mori nucleopolyhedrovirus (BmNPV) despite having originated from the same tissue source. BmN-SWU1 cells were susceptible and supported high titers of BmNPV replication, while BmN-SWU2 cells were resistant to BmNPV inf...

We consider a BMN operator with one scalar, φ and one vector, DμZ, impurity field and compute the anomalous dimension both at planar and torus levels. This mixed operator corresponds to a string state with two creation operators which belong to different SO(4) sectors of the background. The anomalous dimension at both levels is found to be the same as the scalar impurity BMN operator. At planar...

Purpose: PARP1/2 inhibitors are a class of anticancer agents that target tumor-specific defects in DNA repair. Here, we describe BMN 673, a novel, highly potent PARP1/2 inhibitor with favorable metabolic stability, oral bioavailability, and pharmacokinetic properties. Experimental Design: Potency and selectivity of BMN 673 was determined by biochemical assays. Anticancer activity either as a si...

Program Bersinergi Mambangun Nagari (BMN) merupakan program pemberdayaan komunitas yang dilakukan oleh CSR PT Semen Padang untuk menjangkau masyarakat sekitar perusahaan. Penelitian ini bertujuan untuk: (1) menganalisis proses komunikasi dalam (BMN); (2) partisipasi penerima manfaat BMN; dan (3) hubungan terhadap opini publik atau citra perusahaan melalui BMN. menggunakan survei dengan pengumpu...

Pemindahtanganan merupakan salah satu metode dalam melaksanakan penghapusan Barang Milik Negara (BMN) dari daftar pembukuan aset negara. Kementerian Keuangan Republik Indonesia menerbitkan Peraturan Menteri (PMK) Nomor 165 pada tahun 2021 atas perubahan peraturan sebelumnya tentang prosedur pelaksanaan pemindahtanganan BMN. Tujuan penelitian yakni dapat mengetahui bagaimana BMN di Kantor Pelaya...