نتایج جستجو برای: B and T Lymphocyte Attenuator

تعداد نتایج: 17065848  

Journal: :Journal of immunology 2006
Christine Deppong Twyla I Juehne Michelle Hurchla Lindzy D Friend Dulari D Shah Christine M Rose Traci L Bricker Laurie P Shornick Erika C Crouch Theresa L Murphy Michael J Holtzman Kenneth M Murphy Jonathan M Green

T cell activation is regulated by coordinate interaction of the T cell Ag receptor and costimulatory signals. Although there is considerable insight into processes that regulate the initiation of inflammation, less is known about the signals that terminate immune responses. We have examined the role of the inhibitory receptors programmed death receptor-1 and B and T lymphocyte attenuator in the...

Anshan Zhuo Qingyu Xiu Wei Nie Yongan Liu Yu Jin Yuansheng Zang

Background: MicroRNA-155 (miR-155) is upregulated during T cell activation, but the exact mechanisms by which it influences CD4+ T cell activation remain unclear. Objective: To examine whether the B and T lymphocyte attenuator (BTLA) is a target of miR-155 during naïve CD4+ T cell activation. Methods: Firefly luciferase reporter plasmids pEZX-MT01-wild-type-BTLA and pEZX-MT01-mutant-BTLA were ...

2009
Yang-Xin Fu Klaus Pfeffer Lieping Chen Jonathan Kaye Mendy L. Miller Youjin Lee Yang Wang Yonglian Sun Nicholas K. Brown Matthew J. Ruddy Kenneth M. Murphy

2013
Edward R Sherwood Richard S Hotchkiss

Recent research indicates that T-lymphocyte dysfunction may contribute to sepsis-associated morbidity and mortality. B and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor expressed by T lymphocytes and B lymphocytes that is important in regulating lymphocyte activation during inflammation and infection. Shubin and colleagues report that higher mean BTLA expression in critically ill p...

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