Introduction Juvenile Systemic Lupus Erythematous (JSLE) is characterised by auto-antibody production directed against nuclear auto-antigens. Toll-like receptors (TLRs) are pattern recognition receptors of the innate immune system responsible for initiating an immune response against invading pathogens. TLR 3, 7-9 have been studied in SLE due to their unique ability to detect nuclear antigen. T...

Malignant melanoma is one of the most aggressive types of tumor. Because malignant melanoma is difficult to treat once it has metastasized, early detection and treatment are essential. The search for reliable biomarkers of early-stage melanoma, therefore, has received much attention. By using a novel method of screening tumor antigens and their auto-antibodies, we identified bullous pemphigoid ...

Studies suggest certain stimuli like apoptosis behind the aberrant expression of circulating specific auto-antibodies in Type-1 diabetic patients. In present study, we investigated whether Streptozotocin (a diabetogenic compound) induced Rat RINm5f Insulinoma cells can expose immunogenic cryptic antigens. A time course treatment with 4 mM revealed 6hrs as minimal period to induce without much e...

In order to obtain an ultra-sensitive molecular biosensor, we designed an auto-biotinylated bifunctional protein nanowire (bFPNw) based on the self-assembly of a yeast amyloid protein, Sup35, to which protein G and a biotin acceptor peptide (BAP) were genetically fused. These auto-biotinylated bFPNws can transfer hundreds of commercially available diagnostic enzymes to an antigen-antibody compl...

Non-motorized vehicles (i.e. rickshaws) and small size motorized vehicles (i.e. auto-rickshaws) are popular para-transit modes that provided door-to-door service in congested parts of Dhaka metropolitan area. Improper design of signal timing at signalized intersections is one of the reasons of traffic congestion in Dhaka metropolitan area. For capacity analysis, to convert the mixed traffic flo...

Despite the critical role of the Langerhans cells in the induction of contact hypersensitivity reactions, non-Langerhans antigen-presenting cells in already sensitized individuals may play a role in the elicitation phase of a contact hypersensitivity reaction. Following epicutaneous challenge with antigens, the number of CD1+DR+ epidermal Langerhans cells increased in a time-dependent way and, ...