نتایج جستجو برای: Auraptene

تعداد نتایج: 86  

2017
Min-Jin Kim Sang Suk Kim Kyung-Jin Park Hyun Joo An Young Hun Choi Nam Ho Lee Chang-Gu Hyun

Auraptene is the most abundant naturally occurring geranyloxycoumarin. It is primarily isolated from plants belonging to the Rutaceae family, many of which, such as citrus fruits, are used as food in many countries. Auraptene is a biologically active secondary metabolite that possesses valuable properties. The aim of this study was to investigate the in vitro inhibitory effects of auraptene on ...

2011
Tasha Toliver Madhavi Chintalapati Jack N. Losso

The objective of this research was to test the in vitro anti-angiogenic activity of auraptene, a coumarin from citrus peel oil. We tested the ability of auraptene to inhibit in vitro angiogenesis using vascular endothelial growth factor (VEGF)-induced human umbilical endothelial cells (HUVEC) growth stimulation. Auraptene was applied at concentrations between 0 μM and 1μM to HUVEC in the presen...

2015
Bibi Marjan Razavi Ebrahim Arasteh Mohsen Imenshahidi Mehrdad Iranshahi

OBJECTIVES Auraptene, a monoterpene coumarin from Citrus species, exhibits cardioprotective effects. In this study, the effects of auraptene administration were investigated on blood pressure of normotensive and desoxycorticosterone acetate (DOCA) salt induced hypertensive rats. MATERIALS AND METHODS Five weeks administration of auraptene (2, 4, 8 and 16 mg/kg/day) and nifedipine (0.25, 0.5, ...

2012
Prasad Krishnan Heather Kleiner-Hancock

Auraptene is being investigated for its chemopreventive effects in many models of cancer including skin, colon, prostate, and breast. Many mechanisms of action including anti-inflammatory, antiproliferative, and antiapoptotic effects are being suggested for the chemopreventive properties of auraptene. We have previously shown in the N-methylnitrosourea induced mammary carcinogenesis model that ...

Journal: :Carcinogenesis 1999
T Tanaka H Sugiura R Inaba A Nishikawa A Murakami K Koshimizu H Ohigashi

The modifying effects of auraptene isolated from the peel of citrus fruit (Citrus natsudaidai Hayata) on macrophage and lymphocyte functions were investigated in mice. Female BALB/c mice were gavaged with auraptene at a dose of 100, 200 or 400 mg/kg once a day for 10 consecutive days. Glucose consumption of peritoneal macrophages was significantly higher than that in the control group (P < 0.05...

2006
Takuji Tanaka Kunihiro Kawabata Mikio Kakumoto Akira Harà Akira Murakami Wataru Kuki Yasuo Takahashi Hiroshi Yonei Masayo Maeda Takahide Ota Shizuo Odashima Tetsuro Yamane Koichi Koshimizu Hajime Ohigashi

In our previous short-term experiment. Citrus auraptene inhibited the development of azoxymethane (AOM)-induced aberrant crypt foci, which are precursor lesions for colorectal carcinoma. In the present study, the possible inhibitory effect of dietary administration of auraptene was investigated using an animal colon carcinogenesis model with a colon carcinogen AOM. Male F344 rats were given s.c...

2015
Seyed Hadi Mousavi Atiyeh-Sadat Davari Mehrdad Iranshahi Sarvenaz Sabouri-Rad Zahra Tayarani Najaran

OBJECTIVE 7-prenyloxycoumarins are a group of secondary metabolites that are found mainly in plants belonging to the Rutaceae and Umbelliferae families. This study was designed to evaluate and compare the cytotoxic and apoptotic activity of 7-prenyloxycoumarin compounds and herniarin on MCF-7, a breast carcinoma cell line. MATERIALS AND METHODS Cells were cultured in RPMI medium and incubated...

1998
Takuji Tanaka Kunihiro Kawabata Mikio Kakumoto Akira Harà Akira Murakami Wataru Kuki Yasuo Takahashi Hiroshi Yonei Masayo Maeda Takahide Ota Shizuo Odashima Tetsuro Yamane Koichi Koshimizu Hajime Ohigashi

In our previous short-term experiment. Citrus auraptene inhibited the development of azoxymethane (AOM)-induced aberrant crypt foci, which are precursor lesions for colorectal carcinoma. In the present study, the possible inhibitory effect of dietary administration of auraptene was investigated using an animal colon carcinogenesis model with a colon carcinogen AOM. Male F344 rats were given s.c...

Journal: :Genetics and molecular research : GMR 2016
X D Ye H Ouyang L Y Zhong T E Li X Y Rao Y L Feng W L Yang

A simple, sensitive and specific liquid chromatography-tandem mass spectrometry method was developed and validated for the determination of auraptene, a constituent isolated from Fructus aurantii with potential to combat Alzheimer's disease, in rat plasma. Rat plasma samples were pretreated by protein precipitation with methanol. The analytes were separated by a Waters Sun Fire C18 column (50 m...

Journal: :Bioscience, biotechnology, and biochemistry 2006
Kyuichi Kawabata Akira Murakami Hajime Ohigashi

Previously we reported that auraptene was a potent suppressant for matrix metalloproteinase (MMP)-7 expression in HT-29 human colon cancer cells. In the present study, we examined the effects of auraptene on MMP-2, -7, and -9 expression in colonic mucosa from dextran sulfate sodium (DSS)-induced ulcerative colitis mice. Auraptene remarkably suppressed the DSS-induced gelatinolytic activity of M...

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