نتایج جستجو برای: Atropisomers

تعداد نتایج: 126  

Journal: :Dalton transactions 2012
Ashlee J Howarth David L Davies Francesco Lelj Michael O Wolf Brian O Patrick

Two stable diastereomeric atropisomers of a cyclometallated iridium complex containing a pyrene functionalized pyridine imine ligand have been isolated. These are the first fully characterized examples of metal containing atropisomers in which the rotational axis is not between two chelating atoms. The atropisomers can be converted thermally via a rocking motion of the pyrene moiety.

Journal: :Chemical communications 2012
Sergio Grunder J Fraser Stoddart

A series of oligoparaxylene model compounds with two to six paraxylene units was synthesised and the resulting mixtures of atropisomers with one to five axes of chirality were analysed by dynamic (1)H NMR spectroscopy. The number of atropisomers was found to constitute part of the Losanitsch series.

Journal: :Analytical chemistry 2002
Walter Vetter Wu Jun

A hexachloro congener (Q1-hex) of the natural heptachloro-1'-methyl-1,2'-bipyrrole Q1 was recently observed as a byproduct of the Q1 synthesis. NMR investigation confirmed that Q1-hex has a proton on a carbon in beta-position to a nitrogen. Three isomers are possible that fulfill this prerequisite; unfortunately, however, the NMR data were not sufficient to distinguish among the three structura...

2017
Ling Zhang Yue Hu Elizabeth Galella Frank P. Tomasella William P. Fish

In the pharmaceutical industry, the analysis of atropisomers is of considerable interest from a scientific and regulatory perspective. The compound of interest contains two stereogenic axes due to the hindered rotation around the single bonds connecting the aryl groups, which results in four potential configurational isomers (atropisomers). The separation of the four atropisomers is achieved on...

Journal: :Dalton transactions 2015
Daniel J Meininger Nicanor Muzquiz Hadi D Arman Zachary J Tonzetich

Iron complexes of the meso-(tetraaryl)porphyrin, 5,10,15,20-tetrakis(2-chloro-6-fluorophenyl)porphine (H2ClFTPP) are reported. This unique ligand affords the opportunity to study atropisomerism in a porphyrin system containing similar substituents in the 2 and 6 positions of the meso-aryl rings. The atropisomerism displayed by the iron porphyrinates is observed to be a function of both the oxid...

Journal: :Journal of the American Chemical Society 2013
Madalyn R Radlauer Aya K Buckley Lawrence M Henling Theodor Agapie

Dinickel bisphenoxyiminato complexes based on highly substituted p- and m-terphenyl backbones were synthesized, and the corresponding atropisomers were isolated. In the presence of a phosphine scavenger, Ni(COD)2, the phosphine-ligated syn-dinickel complexes copolymerized α-olefins and ethylene in the presence of amines to afford 0.2-1.3% α-olefin incorporation and copolymerized amino olefins a...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2014
Dongren Yang Izabela Kania-Korwel Atefeh Ghogha Hao Chen Marianna Stamou Diptiman D Bose Isaac N Pessah Hans-Joachim Lehmler Pamela J Lein

We recently demonstrated that polychlorinated biphenyl (PCB) congeners with multiple ortho chlorine substitutions sensitize ryanodine receptors (RyRs), and this activity promotes Ca²⁺-dependent dendritic growth in cultured neurons. Many ortho-substituted congeners display axial chirality, and we previously reported that the chiral congener PCB 136 (2,2',3,3',6,6'-hexachlorobiphenyl) atropselect...

Journal: :Chemical communications 2007
Martin Walko Ben L Feringa

All three atropisomers of photochromic diarylethenes were isolated for the first time and the stereospecific photochemical switching process studied by UV-vis and CD spectroscopy.

2013
Guangshu Zhai Xianai Wu Hans-Joachim Lehmler Jerald L Schnoor

BACKGROUND Polychlorinated biphenyls (PCBs) are a group of environmental persistent organic pollutants, which can be metabolized into a series of metabolites, including hydroxylated metabolites (OH-PCBs) in biota. Nineteen of 209 PCB congeners can form chiral stable isomers. However, atropisomeric determination of the hydroxylated metabolites of these chiral PCBs has never been reported by LC m...

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