although the biokinetics, metabolism, and chemical toxicity of atorvastatin calcium are well known, until recently little attention was paid to the potential toxic effects of atorvastatin calcium on re-production and development in mammals. in recent years, it has been shown that atorvastatin calcium is a developmental toxicant when given orally or subcutaneously (sc) to mice. decreased fertili...

Although the biokinetics, metabolism, and chemical toxicity of atorvastatin calcium are well known, until recently little attention was paid to the potential toxic effects of atorvastatin calcium on re-production and development in mammals. In recent years, it has been shown that atorvastatin calcium is a developmental toxicant when given orally or subcutaneously (SC) to mice. Decreased fertili...

Volume 1(2) March-April 2013 Page 244 SIMULTANEOUS ESTIMATION OF OLMESARTAN AND ATORVASTATIN IN BULK AND FROMULATION BY USING UV SPECTROSCOPY AND RP-HPLC Revanth Reddy B * , Aravind G Nimra college of pharmacy, Vijayawada *Corresponding author: E.mail: [email protected] ABSTRACT Simple, rapid and accurate UV Spectroscopic (Simultaneous Equation method and First order derivative method) a...

The use of statins may have unnatural effects. A 54-year-old woman was admitted to the hospital with an incidental finding of hypercalcemia (10.8 mg/dL). There was no disease other than hyperlipidemia, and the patient had been on a course of atorvastatin calcium 10 mg for 1.5 years. A workup investigation to diagnose the cause of hypercalcemia was completed. The investigation did not reveal any...

Three accurate, precise, sensitive and economical procedures for simultaneous estimation of Atorvastatin Calcium and Telmisartan in tablet dosage form have been developed. The methods employed were absorbance correction method (I), first order derivative spectroscopic method (II) and duel wavelength method (III). The first method employs wavelength 328 nm for direct estimation of Telmisartan wh...

A reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of atorvastatin calcium and fenofibrate in tablet formulation. The separation was achieved by Luna C18 column and methanol:acetate buffer pH 3.7 (82:18 v/v) as mobile phase, at a flow rate of 1.5 ml/min. Detection was carried out at 248 nm. Retention time of atorvastatin calcium and feno...

A simple, accurate and precise high-performance thin-layer chromatographic method has been developed for the estimation of Atorvastatin Calcium and Metoprolol Tartarate simultaneously from a capsule dosage form. The method employed Silica gel 60F (254s)precoated plates as stationary phase and a mixture of Chloroform: Methanol: Glacial acetic acid (dil.) :: (9:1.5:0.2 ml %v/v) as mobile phase. D...

background and objectives: lipoprotein-a potentially represents a useful tool for risk stratification in cardiovascular accidents.  the aim of this study was to evaluate the atorvastatin effect on serum lipid profile & lipoprotein a. material & methods: in 2009, 405 patients with acute coronary syndrome randomly were divided into 2 groups, taking 20 & 40 mg atorvastatin daily for 3...

BACKGROUND If literature protocols are followed, conversion of an advanced ketal ester intermediate (available in kilogram quantities via a published Paal-Knorr synthesis) to cholesterol-lowering drug atorvastatin calcium is hampered by several process issues, particularly at the final stage where the hemi-calcium salt is obtained. RESULTS We developed a high-yielding synthesis of atorvastati...

Plasticity of vascular smooth muscle cells (VSMCs) plays a central role in the onset and progression of proliferative vascular diseases. In adult tissue, VSMCs exist in a physiological contractile-quiescent phenotype, which is defined by lack of the ability of proliferation and migration, while high expression of contractile marker proteins. After injury to the vessel, VSMC shifts from a contra...