While the exploitation of the Sharpless asymmetric dihydroxylation as the source of chirality in the synthesis of acyclic molecules and saturated heterocycles has been tremendous, its synthetic utility toward chiral benzo-annulated heterocycles is relatively limited. Thus, in the search for wider applications of Sharpless asymmetric dihydroxylation-derived diols for the synthesis of benzo-annul...

Samarium is an efficient reducing agent, a radical generator in cyclization and cascade addition reaction. Interestingly, samarium metal has crucial impact on numerous C-C C-X (X = hetero atom) bond forming transformations. It been established as exceptional chemo-selective stereoselective reagent. The reactivity of the catalyst/reagent remarkably enhanced presence various additives, ligands so...