introduction abnormal neural impulses in the nervous system may lead to various diseases and disabilities. high frequency alternating currents (hfac) has been used to block the propagation of such impulses and improve the symptoms or disabilities. the technique is safe, reversible, and relatively selective, and its reliability, the optimum stimulation parameters, and elimination of the onset re...

Introduction Abnormal neural impulses in the nervous system may lead to various diseases and disabilities. High frequency alternating currents (HFAC) has been used to block the propagation of such impulses and improve the symptoms or disabilities. The technique is safe, reversible, and relatively selective, and its reliability, the optimum stimulation parameters, and elimination of the onset re...

introduction: high frequency alternating currents is a safe, reversible and selective method for nerve conduction block that has been under study during the last decade as a treatment for the diseases involving abnormal neural impulses. however, reducing the stimulus amplitude, and the undesired onset response, as well as optimizing the stimulus parameters for more effective block is still unde...

BACKGROUND Biphasic waveforms reduce defibrillation threshold (DFT) in a wide variety of models. Although there are several human studies of long-duration, high-tilt biphasic waveform defibrillation, the specific biphasic waveform shape required to achieve optimal DFT reduction is unknown. METHODS AND RESULTS This study tested the effect of single capacitor biphasic waveform tilt modification...

BACKGROUND Several clinical studies have demonstrated a general superiority of biphasic waveform defibrillation compared with monophasic waveform defibrillation using epicardial lead systems. To test the breadth of utility of biphasic waveforms in humans, a prospective, randomized evaluation of defibrillation efficacy of monophasic and single capacitor biphasic waveform pulses was performed for...

Background. Several clinical studies have demonstrated a general superiority of biphasic waveform defibrillation compared with monophasic waveform defibrillation using epicardial lead systems. To test the breadth of utility of biphasic waveforms in humans, a prospective, randomized evaluation of defibrillation efficacy of monophasic and single capacitor biphasic waveform pulses was performed fo...

OBJECTIVES We compared the efficacy of a novel rectilinear biphasic waveform, consisting of a constant current first phase, with a damped sine wave monophasic waveform during transthoracic defibrillation. BACKGROUND Multiple studies have shown that for endocardial defibrillation, biphasic waveforms have a greater efficacy than monophasic waveforms. More recently, a 130-J truncated exponential...

Cardioversion of atrial fibrillation (AF) using traditional monophasic shock waveform is unsuccessful in up to 20% of cases, and often requires several shocks of up to 360 J. Based on the success with biphasic shock waveform in converting ventricular fibrillation, it was postulated that biphasic shocks would allow cardioversion with lower energy. In a international multicenter, double-blind, ra...

The use of a low tilt biphasic waveform lowers the defibrillation threshold for the internal cardioversion of atrial fibrillation Purpose: Conventional defibrillators used for the internal cardioversion of atrial fibrillation (AF) employ high tilt waveforms generated by a capacitor based discharge. We have developed a biphasic waveform with low tilt. This was compared with a conventional wavefo...

Biphasic defibrillation waveforms are now accepted as being more effective at terminating ventricular fibrillation (VF) than monophasic waveforms. If two phases are better than one, this naturally leads to the hypothesis that additional phases improve efficacy. This study tests the hypothesis by adding one additional phase. We examined the efficacy of 18 different triphasic waveforms simultaneo...