نتایج جستجو برای: Astrogliosis

تعداد نتایج: 1064  

Journal: :Cold Spring Harbor Perspectives in Biology 2014

Journal: :مجله علوم اعصاب شفای خاتم 0
sajad sahab negah a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran b. histology and embryology group, department of basic sciences, faculty of veterinary medicine, shiraz university, shiraz, iran zabihollah khaksar histology and embryology group, department of basic sciences, faculty of veterinary medicine, shiraz university, shiraz, iran mostafa modarres mousavi shefa neuroscience research center, khatam alanbia hospital, tehran, iran ali jahanbazi jahan-abad shefa neuroscience research center, khatam alanbia hospital, tehran, iran arezou eshaghabadi shefa neuroscience research center, khatam alanbia hospital, tehran, iran hassan hossini ravandi shefa neuroscience research center, khatam alanbia hospital, tehran, iran

traumatic brain injury (tbi) can be caused by a wide variety of stimuli and encompasses a large range of severities. tbi has the potential for long-term and gradually increased susceptibility for behavioral disturbances, seizure disorders or neurodegenerative disease. in the healthy central nervous system (cns), astrocytes play important roles in preserving the homeostasis of ions, transmitters...

2015
Ryan Mathur Paul G. Ince Thais Minett Claire J. Garwood Pamela J. Shaw Fiona E. Matthews Carol Brayne Julie E. Simpson Stephen B. Wharton

AIMS β-amyloid (Aβ) plaques are a key feature of Alzheimer's disease pathology but correlate poorly with dementia. They are associated with astrocytes which may modulate the effect of Aβ-deposition on the neuropil. This study characterised the astrocyte response to Aβ plaque subtypes, and investigated their association with cognitive impairment. METHODS Aβ plaque subtypes were identified in t...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
M Rostworowski V Balasingam S Chabot T Owens V W Yong

The relevance of astrogliosis remains controversial, especially with respect to the beneficial or detrimental influence of reactive astrocytes on CNS recovery. This dichotomy can be resolved if the mediators of astrogliosis are identified. We have measured the levels of transcripts encoding inflammatory cytokines in injury systems in which the presence or absence of astrogliosis could be produc...

Journal: :Neural Regeneration Research 2017

2016
Tianjiao Wei Mengni Yi Wen Gu Lina Hou Qin Lu Zhihua Yu Hongzhuan Chen

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline of cognitive function. Astrogliosis plays a critical role in AD by instigating neuroinflammation, which leads ultimately to cognition decline. We previously showed that the intermediate-conductance Ca2+-activated potassium channel (KCa3.1) is involved in astrogliosis-induced by TGF-β in vitro. In the p...

2017
Liyan Hou Xueying Zhou Cong Zhang Ke Wang Xiaofang Liu Yuning Che Fuqiang Sun Huihua Li Qingshan Wang Dan Zhang Jau-Shyong Hong

Astrogliosis has long been recognized in Parkinson's disease (PD), the most common neurodegenerative movement disorder. However, the mechanisms of how astroglia become activated remain unclear. Reciprocal interactions between microglia and astroglia play a pivotal role in regulating the activities of astroglia. The purpose of this study is to investigate the mechanism by which microglia regulat...

2017

Submit Manuscript | http://medcraveonline.com potential proand anti-epileptogenic effects [1,2]. Given that epilepsy can be associated with neurodegeneration, mossy fiber sprouting and changes in receptor and neurotransmitter function, examining the specific role of reactive astrogliosis in epilepsy has been fraught with difficulties. Previously, a transgenic mouse line was generated [3] where ...

Journal: :Neuroscience letters 2014
Stephanie Hostenbach Melissa Cambron Miguel D'haeseleer Ron Kooijman Jacques De Keyser

Neuroinflammation can lead to either damage of astrocytes or astrogliosis. Astrocyte loss may be caused by cytotoxic T cells as seen in Rasmussen encephalitis, auto-antibodies such as in neuromyelitis optica (aquaporin-4 antibodies), or cytokines such as TNF-α in major depressive disorder. Interleukins-1 and -6 appear to be important molecular mediators of astrogliosis. Chronic focal lesions in...

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