نتایج جستجو برای: Arundic acid

تعداد نتایج: 747443  

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Takashi Mori Terrence Town Jun Tan Nobumichi Yada Yuko Horikoshi Junki Yamamoto Taiji Shimoda Yoshihisa Kamanaka Narito Tateishi Takao Asano

Like microglia, reactive astrocytes produce a myriad of neurotoxic substances in various brain pathologies, such as Alzheimer's disease (AD), trauma, and cerebral ischemia. Among the numerous products of reactive astrocytes, attention has recently been directed toward the possible detrimental role of S100B, because the protein has been shown to be highly expressed along with the progression of ...

Objective(s): Valproic and arundic acids are astrocytes-modulating agents with potential effects in the treatment of Alzheimer’s disease (AD). S100B is an astrocytic cytokine with a possible role in the pathogenesis of AD. In this study, we aimed to assess the glioprotective effects of valproic and arundic acids against amyloid-β-peptide (Aβ)-induced glial death and co...

2017
Marlene M. Hao Elena Capoccia Carla Cirillo Werend Boesmans Pieter Vanden Berghe

S100B is expressed in various types of glial cells and is involved in regulating many aspects of their function. However, little is known about its role during nervous system development. In this study, we investigated the effect of inhibiting the onset of S100B synthesis in the development of the enteric nervous system, a network of neurons and glia located in the wall of the gut that is vital...

Journal: :Neuroscience Letters 2021

Astrocytes respond to injury by modifying the expression profile of several proteins, including S100 calcium-binding protein B (S100B), assumed be a marker as well mediator brain injury. AA is an inhibitor S100B synthesis and plays protective role in different models injury, decreases cause extracellular S100B. However, mRNA expression, content secretion do not always occur association; such, w...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه علوم کشاورزی و منابع طبیعی ساری - دانشکده علوم کشاورزی 1393

قارچ ها به عنوان یکی از مهمترین عوامل بیماریزای گیاهی، منبع اصلی از متابولیت های ثانویه بیواکتیو هستند، و از اهمیت قابل توجهی در فعل و انفعالات زیست محیطی برخوردار می باشند از جمله متابولیت ها می توان آنتی بیوتیک ها، توکسین ها و آنزیم ها را نام برد. در این پژوهش شناسایی متابولیت های ثانویه تولید شده در 21 گونه قارچی با کمک gc – ms انجام گردید. نتایج حاصل از بررسی قابلیت ضد باکتریایی، ضد قارچی، ...

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