Background: Artemisinin is commonly used for the treatment of malaria, but recently has been considered as a potential substance to control poultry coccidiosis. OBJECTIVES: The aim of the present study was to determine the tissue distribution of artemisinin following single or multiple oral administration of different doses in broiler chickens. METHODS: A total number of 390 one day old Ross br...

In this study we examined enhancement effects of Artemisinin plus Glucantime and shark cartilage extract, on promastigotes and amastigotes of L.infantum in in vitro condition.The toxicity of artemisinin, glucantime and shark cartilage extract on the L. infantum promastigotes and amastigote-infected macrophages was evaluated using MTT assay. The role of these drugs in inducing apoptosis in proma...

Abstract: The aim of the present study was to produce a polyclonal antibody against bovine serum albumin (BSA) conjugated with artemisinin. To gain an immunogenic character of artemisinin, a carboxyl group was added to it using mixed anhydride method. Then, the reactive compound of artemisinin was conjugated with BSA. The BSA+artemisinin were injected to white female New Zealand rabbits for two...

In this study we examined enhancement effects of Artemisinin plus Glucantime and shark cartilage extract, on promastigotes and amastigotes of L.infantum in in vitro condition.The toxicity of artemisinin, glucantime and shark cartilage extract on the L. infantum promastigotes and amastigote-infected macrophages was evaluated using MTT assay. The role of these drugs in inducing apoptosis in proma...

background: artemisinin is commonly used for the treatment of malaria, but recently has been considered as a potential substance to control poultry coccidiosis. objectives: the aim of the present study was to determine the tissue distribution of artemisinin following single or multiple oral administration of different doses in broiler chickens. methods: a total number of 390 one day old ross br...

Artemisinin drug resistance is one of the major reasons for malaria treatment failures in sub-Saharan African countries where artemisinin-based combination therapy (ACT) first-line uncomplicated malaria. The occurrence single nucleotide polymorphisms (SNPs) found to correlate with antimalarial resistance. With artemisinin, SNPs occurs at Kelch 13-propeller gene locus on chromosome 13. artemisin...

artemisinin, a secondary metabolite, is produced by artemisia annua l. plant and is nowadays, the most effective drug in the treatment of malaria. this component and its derivatives are also used against hepatitis b and different types of cancers. chemical synthesis of artemisinin is possible but because of its complex structure and low yield, it is not economically feasible. since this plant s...

Artemisia annua is the source of antimalarial phytomolecule, artemisinin. It is mainly produced and stored in the glandular secretory trichomes present in the leaves of the plant. Since, the artemisinin biosynthesis steps are yet to be worked out, in this investigation a microarray chip was strategized for the first time to shortlist the differentially expressing genes at a stage of plant produ...

malaria is currently one of the most important causes of mortality in developing countries. high resistance to available antimalarial drugs has been reported frequently, thus it is crucial to focus on the discovery of new antimalarial drugs. artemisinin, an effective antimalarial medication, is isolated from various artemisia species. to identify the artemisia species producing high quantity of...

Malaria is still considered as the major parasitic disease and development of artemisinin resistance does not improve this alarming situation. Based on recent identification relevant malaria targets in context, novel drug combinations were evaluated against artemisinin-sensitive artemisinin-resistant Plasmodium falciparum parasites. Corresponding hybrid molecules also synthesized for comparison...