objective(s):   zinc oxide nanoparticles (znp) are increasingly used in sunscreens, biosensors, food additives and pigments. in this study the effects of znp on liver of rats was investigated.     materials and methods: experimental groups received 5, 50 and 300 mg/kg znp respectively for 14 days. control group received only distilled water. alt, ast and alp were considered as biomarkers to ind...

introduction: acrylamide (acr) known as a neurotoxic agent in human and animals. previous studies have been shown; fasudil improves neurological deficit and neuronal damage. in this study, the effect of fasudil, potent rho-kinase inhibitor, on acr-induced cytotoxicity was evaluated using pc12 cells as a suitable in vitro model. materials and methods: pc12 cells were exposed to different concent...

young children with history of maternal stress during pregnancy suffer from several neurological and psychological disorders in the childhood. the purpose of this study was to investigate the effect of maternal stress during pregnancy on the neural apoptosis in the newborns. pregnant wistar rats were divided into control and stress groups. stress was applied on the pregnant females from day 15 ...

the study was conducted to evaluate the effect of thermal stress on expression profile of genes related to apoptosis in peripartum sahiwal cows. for this, twelve pregnant dry sahiwal cows were selected from livestock research centre at national dairy research institute, karnal. the cows were divided into two groups consisting of six sahiwal cows each. cows of group i calved during thermoneutral...

background noise pollution causes of apoptosis in germinal cells of testes. this study investigated the effects of honey and vitamin e administration on the process of apoptosis in cells of the germinal testis of rats exposed to noise stress. material and methods in this study, 24 male wistar rats randomly grouped as: 1 (honey + noise stress), 2 (vitamin e + noise stress) 3 (noise stress) and g...

cirrhosis is associated with hyperdynamic circulation, manifesting as increased cardiac output and decreased systemic vascular resistance. the aim of this study was to investigate the effect of cirrhosis on heart apoptosis and involvement of nitric oxide (no) and oxidative stress in the possible altered apoptosis of cirrhotic hearts. twenty-eight days after bile duct ligation, heart tissues wer...

results the mean number and size of betz cells in the stressed group decreased significantly compared to those in the control group (p < 0.05). qualitative observations revealed chromatolysis of nissl bodies, nucleus condensation, and a decrease in neural processes. the mean number of apoptotic cells in the stressed group were also significantly increased compared to that of the control group (...

isolated rat hepatocytes in culture were incubated with different concentrations of iron-sorbitol (50, 100, 150, and 200 µm) to assess the changes in reactive oxygen species (ros) and lipid peroxidation leading to apoptotic hepatocyte cell death. the viability of hepatocytes was declined depending on the iron concentration. one hour incubation of the cells with 100 µm iron resulted in decreased...

objective(s): hyperglycemia, oxidative stress and apoptosis have key roles in pathogenesis of diabetic neuropathy. there are local renin-angiotensin systems (rass) in different tissues such as neural tissue. local rass are involved in physiological and pathophysiological processes such as inflammation, proliferation and apoptosis. this study aimed to investigate the role of local renin-angioten...

objective(s): in the current study antioxidant capacities of five different extracts of artemisia ciniformis aerial parts were evaluated by cell-free methods. then seven fractions of the potent extract were selected and their antioxidant capacity was assayed by cell free and cell based methods. materials andmethods: antioxidant ability was measured using the: 2, 2-diphenyl-1-picrylhydrazyl (dpp...