this work was to isolate and identify the bioactive secondary metabolite which was produced by myxobacterium stigmatella eracta wxnxj-b, and to evaluate its antitumor and apoptosis-inducing effects. the results showed that one novel compound (molecular formula c29h25no3) was isolated, purified by sephadex lh-20 column chromatography and preparative rp-hplc, and identified as 5-(6-benzyl-quinoli...

PURPOSE In this study, the optimization of antitumor therapy with tumor necrosis factor-alpha (TNF-alpha) was attempted. EXPERIMENTAL DESIGN Using the phage display technique, we created a lysine-deficient mutant TNF-alpha (mTNF-K90R). This mutant had higher affinities to both TNF receptors, despite reports that certain lysine residues play important roles in trimer formation and receptor bin...

Purpose: In this study, the optimization of antitumor therapy with tumor necrosis factor(TNF) was attempted. Experimental Design: Using the phage display technique, we created a lysine-deficient mutant TNF(mTNFK90R). This mutant had higher affinities to both TNF receptors, despite reports that certain lysine residues play important roles in trimer formation and receptor binding. Results: The mT...

BACKGROUND Combretastatin A-4 (CA-4), which is an excellent antineoplastic agent, was isolated from Combretum caffrum. To date, structural modification studies of CA-4 have focused predominantly on the construction of new therapeutic agents for drug discovery. As a part of our ongoing work towards the modification of natural products, we have focused on the 3'-O-substituent groups in the B-ring...

Ganoderma genus comprises one of the most commonly studied species worldwide, Ganoderma lucidum. However, other Ganoderma species have been also reported as important sources of bioactive compounds. Polysaccharides are important contributors to the medicinal properties reported for Ganoderma species, as demonstrated by the numerous publications, including reviews, on this matter. Yet, what are ...

Biomedical inorganic chemistry is a relative new research field and investigates possible applications of metal containing agents which display biological activities!,2. An important part of these studies deals with compounds that display antitumor properties. The most successful anticancer drug to date containing a transition metal is cisplatin, [Pt(NH3)2Ch]3. The bioactivity of organometallic...

Paris polyphylla Smith var. yunnanensis, has been used in traditional Chinese medicine for its antibiotic and anti-inflammatory properties; in addition it has been used to cure liver cancer in particular. In this current study, β-ecdysterone (1) and three pennogenin steroidal saponins (2-4) were isolated from the EtOH extract of Paris polyphylla var. yunnanensis, and then tested for their antit...

paris polyphylla smith var. yunnanensis, has been used in traditional chinese medicine for its antibiotic and anti-inflammatory properties; in addition it has been used to cure liver cancer in particular. in this current study, β-ecdysterone (1) and three pennogenin steroidal saponins (2-4) were isolated from the etoh extract of paris polyphylla var. yunnanensis, and then tested for their antit...