Quaternized chlorpromazine, triflupromazine, and promethazine derivatives were synthesized and examined as antitubercular agents against both actively growing and non-replicating Mycobacterium tuberculosis H37Rv. Impressively, several compounds inhibited non-replicating M. tuberculosis at concentrations equal to or double their MICs against the actively growing strain. All active compounds were...

we report 11 year old male child, a case of acquired aplastic anemia as a complication of disseminated tuberculosis with acute onset, rapid downhill course and refractory to both antitubercular drugs as well as immunosuppressive drugs.

Due to the increasing emergence of drug resistant Tuberculosis (TB), particularly multidrug resistant TB (MDR-TB), extensive-drug resistant TB (XDR-TB) and also the development of resistance in the micro-organisms against available drugs there is a need to develop new, potent, fast-acting antibacterial and antitubercular drugs with low toxicity. With this aim different extracts of Phaseolus vul...

Mycobacterium tuberculosis is the causative agent of tuberculosis, an ancient disease which, still today, represents a major threat for the world population. Despite the advances in medicine and the development of effective antitubercular drugs, the cure of tuberculosis involves prolonged therapies which complicate the compliance and monitoring of drug administration and treatment. Moreover, th...

98 patients with tuberculous meningitis were studied with a view to assessing the value of steroids as an adjuvant to antitubercular drugs. The patients were divided into three groups irrespective of the clinical stage of the disease. One group received antitubercular drugs alone, the second oral prednisolone, and the third intrathecal steroids, in addition to the antitubercular drugs. There wa...

BACKGROUND Rifampicin induces expression of the cytochrome P450 isoenzyme 2B6 (CYP2B6), which metabolizes efavirenz. The CYP2B6 516G>T polymorphism impairs efavirenz metabolism and occurs more commonly in Africans than in Caucasians. We explored the effect of rifampicin-based antitubercular therapy and the 516G>T polymorphism on efavirenz concentrations in HIV-infected patients in South Africa....

OBJECTIVES A novel and simple method to synthesize antitubercular-protein conjugate by solid phase synthesis was developed employing a carboxypolystyrene resin. The aim was to covalently bind a drug with antitubercular activity, isoniazid, to a biomacromolecule, gelatin, widely used in the pharmaceutical, cosmetic and food industry. METHODS Calorimetric and (1) H NMR analyses were performed t...

Keeping in view the drawbacks associated with research on anti-TB drugs based on plant extracts and the non-availability of fluorinated natural products with antitubercular activity has prompted us to make an effort towards the synthesis and characterization of a novel series of fifteen substituted fluorobenzimidazoles. The newly synthesized compounds were characterized by I.R, 1H-NMR, 13C-NMR,...

Recently, one third of the world’s population is infected with Mycobacterium tuberculosis and 8 million new and relapse cases of tuberculosis are reported every year. The emergence of new cases, the increased incidence of multidrug resistant strains of M. tuberculosis, and the adverse effects of first and second-line antituberculosis drugs have led to renewed research interest in natural produc...

Tuberculosis was declared as a global pandemic and panic because the causative Mycobacterium tuberculosis can kill an incredible number of individuals which formulate a major obstacle to social and economic development of the country. Most of the developing countries are affected by tuberculosis. Antitubercular therapy involves the use of Directly Observed Therapy Short (DOTS) course for 6-9 mo...