background and objective: n-methyl-d-aspartate (nmda) antagonists such as piperidines are the most important antiepileptic drugs. considering the fact that piperidine derivatives such as phencyclidine (pcp) and its new derivative, 1-[1-(3-methoxyphenyl) (tetralyl)] piperidine (pcp1), have different potencies, the antiepileptic effects of mentioned drugs were investigated in the present study. ...

objective(s):paclitaxel is a potent chemotherapy agent with severe side effects, including allergic reactions, cardiovascular problems, complete hair loss, joint and muscle pain, which may limit its use and lower its efficiency. the cardioprotective effect of royal jelly was investigated on paclitaxel-induced damages. materials and methods:adult male wistar rats were divided into control and te...

the aim followed in the present study was to evaluate the antioxidant activity of individual vs. combined extracts of rosemary leaves and oak fruit to detect the possible interactions in their antioxidant activity following combination and in order to find a way to use oak fruit natural antioxidants as an available massive source in iran. towards this end, methanolic extracts of rosemary and oa...

background: applications of natural ingredients not only increase the shelf life of food but also omit the problems of synthetic preservatives compounds. objective: cinnamon verum essential oil (cveo 0.05, 0.1, 0.15%) and echinacea purpurea extract (epe 0.25, 0.5, 0.75%) were added to kolompe (a traditional cookie in kerman-iran) and their antioxidant and antimicrobial effects were compared wit...

phenolic and flavonoid compounds are secondary metabolites of plants which possess various activities such as anti-inflammatory, analgesic, anti-diabetes and anticancer effects. it has been established that these compounds can scavenge free radicals produced in the body. because of this ability, not only the plants containing phenolic and flavonoid compounds but also, the pure compounds are use...

mycophenolate mofetil (mmf) as an immunosuppressive agent is used to prevent graft rejection. one of the adverse effects of long time administration of mmf is the gastrointestinal disorder. this study aimed to investigate the gastroprotective effect of silymarin (smn) on mmf-induced gastrointestinal (gi) disorders. twenty-four adult female wistar rats were assigned into three groups including t...

phenolic compounds including flavonoids and phenolic acids are plants secondary metabolites. due to their ability to act as antioxidant agents, there is a growing interest to use those components in traditional medicine for cancer prevention or treatment. the aim of this study was to measure the amounts of total phenolics and flavonoids as well as anti-proliferative effect of aqueous extract of...

background and objective: although there are reports in the literature on the antimicrobial effects of green tea, the effect of black tea, the most common beverage in iran, on growth of bacteria, such as streptococcus pyogenes, has not been studied extensively. this study was undertaken to determine the inhibitory effect of black tea on the growth of streptococcus pyogenes in vitro and compare ...

a series of copper and cobalt substituted nanospinel ferrites have been synthesized by the hydrothermal method. these compounds were characterized by ft-ir, xrd, edx, sem and vsm techniques. all of the synthesized nanospinel ferrites were found to be highly efficient and magnetically recoverable in the solvent-free synthesis of substituted 2,6-(2-hydroxybenzyl)-phenols (trisphenols). a wide ran...

objective: to evaluate the hepatoprotective properties of otostegia persica (o. persica) ethanol extract on carbon tetrachlo­­ride-induced liver damage in rats. materials and methods: fifty adult male wistar rats were randomly divided into five groups. group i served as normal control and was given only olive oil intraperitoneally (i.p.). group ii, iii, iv, and v were administered ccl4 mixed wi...